Lg Innotek Co., Ltd.

Sk Planet Co., Ltd.

Industry-Academic Cooperation Foundation, Dankook University

Rznomics Inc.

Seong Wook Lee

Jin Sung Kim

Jae Soo Yoo

Jong Woo Yoo

Ju A Yoo

Sang-Bum Kim

Sung Jin Kim

Ju Hyun Kim

Young Sook Hwang

Chang Hao Yin

Jin Sook Jeong

Hae Chang Rim

Sang Young Han

Bit Na Yang

Seung Ryul Han

Yeon Su Lee

The present invention relates to a recombinant vector, characterized by including a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4)-targeting trans-splicing ribozyme expression cassette for delivery of chimeric antigen receptor, wherein the expression cassette includes: (i) a CTLA-4-targeting trans-splicing ribozyme; and (ii) a polynucleotide encoding a chimeric antigen receptor ligated to the 3' exon of the ribozyme. The present invention also relates to a transformed cell into which the recombinant vector is introduced, a ribozyme expressed from the recombinant vector, a retrovirus expressing the ribozyme, and a T cell treated with the retrovirus. Furthermore, the present invention relates to a pharmaceutical composition for preventing or treating cancers, in which the pharmaceutical composition includes the recombinant vector, the transformed cell, the ribozyme, the retrovirus, the T cell, or a combination thereof; and a method for treating cancers, in which the method includes administering, to an individual in need thereof, the recombinant vector, the transformed cell, the ribozyme, the retrovirus, the T cell, or a combination thereof. The recombinant vector of the present invention and the ribozyme expressed therefrom become a gene-cell therapy which inhibits CTLA-4 on T cells which has been an obstacle in conventional anti-cancer therapies and, at the same time, enables anti-cancer treatment, thereby allowing more effective anti-cancer effects to be anticipated. Such a gene-cell therapy results in decreased toxicity in normal tissues and thus exhibits increased effects in both therapeutic efficacy and safety, which enables it to be widely utilized in the field of gene therapy in the future.

CTLA-4-targeting trans-splicing ribozyme for delivery of chimeric antigen receptor, and use thereof

The present invention relates to a recombination vector, a transformation cell into which the recombinant vector is introduced, a ribozyme expressed from the recombination vector, a prophylactic or therapeutic composition for liver cancer comprising the recombination vector and the ribozyme, and a therapeutic method for liver cancer using the composition, said recombination vector comprising: a tissue-specific promoter; and a ribozyme-target gene expression cassette comprising a trans-splicing ribozyme targeting a cancer-specific gene and a target gene connected to the 3' exon of the ribozyme, wherein a splicing donor/splicing acceptor sequence (SD/SA sequence) is connected to the 5&#x2032; end of the ribozyme-target gene expression cassette, woodchuck hepatitis virus posttranscriptional regulatory element (WPRE) is connected to the 3&#x2032; end of the ribozyme-target gene expression cassette, and a nucleic acid sequence recognizing a micro RNA-122a (microRNA-122a, miR-122a) is further connected to the 3&#x2032; end of the WPRE.

Cancer specific-splicing ribozyme and use thereof

The present invention relates to statistical machine translation, and provides a machine translation device and a machine translation method that acquire a creation probability for a target language from a single corpus while extracting respective conversion probabilities by extracting syntax conversion knowledge and word translation knowledge from a parallel corpus, model a weighted translation model by allowing each of the conversion knowledge and each of the probabilities to learn using a translation model learning device, and generate a target sentence through decoding processes of a syntax converter and a word translator by applying the translation model to a source sentence input in real time, thereby resolving disadvantages of the existing phrase-based SMT and syntax-based SMT and combining advantages thereof.

Machine translation device and machine translation method in which a syntax conversion model and a word translation model are combined

Embodiments of the present invention provide a bluish green phosphor represented by Formula 1 below. In particular, the bluish green phosphor and a light emitting device package including the same may have superior luminescence characteristics and improved temperature stability by selecting composition ratios of each ingredients included in a composition formula and ions and thereby minimizing lattice defects in a crystal structure:ABONG:RE&#x2003;&#x2003;[Formula 1]

Bluish green phosphor and light emitting device package including the same

Embodiments of the present invention provide a bluish green phosphor represented by Formula 1 below. In particular, the bluish green phosphor and a light emitting device package including the same may have improved luminescence characteristics and properties due to influence of cations and anions included in a composition formula:ABONGDE:RE&#x2003;&#x2003;[Formula 1]

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Seoul, South Korea

Seong Wook Lee