Hawaii Biotech, Inc.

Other

Seong Jin Kim

Alan Thomas Johnson

Sean O'Malley

Henry Lee Jackson

Guan-Sheng Jiao

Edward Tak Wei

Alan T Johnson

Compounds of formula I are provided: wherein X is NH, or CH, Y is a single bond, or &#x2014;CHR&#x2014;, Ris H, C-Calkyl, or C-Chydroxyalkyl, Rand R' are each independently H, C-Calkyl, or C-Chydroxyalkyl, each Ris independently H, halo, &#x2014;CF, C-Calkyl, or C-Calkoxy, Cperhaloalkyl, each Ris independently H, halo, or C-Calkyl, Ris C-Calkoxy, r is integer from 0 to 3; and p is integer from 0 to 3.

Pyridin-2-yl alkylamino substituted hydroxamic acid and uses thereof

Compounds of Formula I are provided: Ris &#x2014;OR, m is an integer from 0 to 5, n is an integer from 0 to 2, each Ris independently selected from hydrogen, halogen, and alkyl, Ris selected from hydrogen, alkyl, cycloalkyl, aryl, hydroxyalkyl, alkoxyalkyl, aryloxyalkyl, aralkyloxyalkyl, aralkyl, alkylaminoalkyl, dialkylaminoalkyl, aralkylaminoalkyl, and heterocycloalkyl, Ris an alkyl, each Ris independently hydrogen or alkyl, and each of R, R, R, and Ris independently optionally substituted. Compounds of Formula I are included in pharmaceutical compositions for the treatment of a subject exposed to atoxin.

Hydroxamic acids comprising pyrazole moiety and uses thereof

The present discovery pertains to the discovery of certain amphiphilic compounds that may be useful for the management of sebum secretion in subjects with acne, oily skin, or seborrheic dermatitis. These compounds are 1-dialkylphosphorylalkanes with the longest alkyl group being seven or more carbons. Preferably, a compound is dissolved in a dermatologically acceptable vehicle, and delivered to the skin in a solution, gel, lotion, cream, or ointment. The method of application may be with the surface of the finger, or via an applicator. The decrease is sebum secretion in certain subjects may result in skin conditions that enhance cosmetic appearance and ameliorate skin disorders.

Chemical inhibitors of sebocyte function

Compounds of formula I are provided: Ris an alkoxy or O(CH)X, p is an integer from 2 to 3 and X is OH, NH, or COH, m is an integer from 0 to 5, n is an integer from 0 to 5, each Ris independently selected from hydrogen, alkenyl, hydroxyalkyl, alkoxymethyl, heterocyclyl, hetereocyclylmethyl, amino, amido, hydroxamido, any of which may be optionally substituted with one or more of acyl, alkyl, alkoxy, hydroxyalkyl, or halogen, each Ris independently selected from hydrogen, halogen, alkyl, alkenyl, carboxy, hydroxymethyl, amido, and at least one of Rand Ris not hydrogen.

Growing community of inventors

Honolulu, HI, United States of America

Seong Jin Kim