Lg Chemical Ltd.

Crystalgenomics, Inc.

Korea Research Institute of Chemical Technology

Sbi Biotech Co., Ltd.

Seong Gu Ro

Jong Sung Koh

Jong Hyun Kim

Hyun Il Lee

Hyun Ho Chung

Tae Hwan Kwak

Sun Hwa Lee

In Ae Ahn

You Seung Shin

Hyun Sung Kim

Won Hee Jung

Tae Saeng Choi

Kwi Hwa Kim

Jin Ho Lee

Jung Kwon Yoo

Shin Wu Jeong

Masaaki Sawa

Joong Myung Cho

Dongkyu Shin

Hee Jung Jung

Chika Tanaka

Takayuki Irie

Jae Hak Kim

Sang Woong Kim

Young Lan Hyun

Young Hoon Oh

Kyung Duk Moon

You Seong Shin

Choul Hong Park

Ki Won Park

Cheol Hae Lee

Cheol Soon Lee

Chung Mi Kim

Sayuri Ito

Won Jang Jeong

An object of the present invention is to provide thiazolidinone derivatives. More specifically, an object of the present invention is to provide novel compounds having a CDC7 inhibitory action. The present invention provides thiazolidinone derivatives represented by the formula (I)  The compounds of the present invention inhibit the CDC7 protein kinase activity, and suppress cell proliferation.

Thiazolidinone derivative

The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation.

Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same

The present invention relates to novel imidazole derivatives which show an inhibitory activity against farnesyl transferase, pharmaceutically acceptable salts or isomers thereof and pharmaceutical compositions comprising such imidazole derivatives. More particularly, the present invention relates to intermediate compounds which are used in the preparation of the imidazole derivatives of the invention. Related processes also are disclosed.

Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof

The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1): and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

Farnesyl transferase inhibitors having a piperidine structure and process for preparation thereof

The present invention relates to novel hydantoin compounds represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent, or pharmaceutically acceptable salts thereof, in which R , R , R and R are as defined in the present application. The present invention also relates to a process for preparation of the compound of formula (I), and to an anti-cancer composition comprising the compound of formula (I) as an active ingredient.

Hydantoin compounds and methods related thereto

The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n,and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

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Daejeon, South Korea

Seong Gu Ro