Korea Institute of Science and Technology

Seon Hee Seo

Ae Nim Pae

Hyunah Choo

Kyung Il Choi

Hyewhon Rhim

Yong Seo Cho

Dong Jin Kim

Eun Joo Roh

Gyo Chang Keum

Jae Kyun Lee

Kye Jung Shin

Ghilsoo Nam

Hye Jin Chung

Youngsoo Kim

Hee Sup Shin

Yong Koo Kang

Eunice Eun-Kyeong Kim

Key-Sun Kim

Hesson Chung

Dong Yun Shin

Kee Dal Nam

Hoh Gyu Hahn

Yoon Jee Kim

Woong Seo Park

Hye Ran Kim

Chan Seong Cheong

Kee Hyun Choi

Jung Hyun Kim

Youngjae Kim

Soon Bang Kang

Hun Yeong Koh

Joo Hwan Cha

Ghil Soo Nam

Sun Joon Min

Chi Man Song

Hyun Ah Choo

Jee Yeon Kim

Cheolju Lee

Yoo Ran Ki

Min Joo Kim

Sora Kim

Hyung Kook Lee

Vani Nelamane Devegowda

You Na Oh

Hwa-Sil Kim

Disclosed are thienopyrimidinone derivatives as antagonists that act on metabotropic glutamate receptor subtype 1. The thienopyrimidinone derivatives show pharmacological activity against metabotropic glutamate receptor-related diseases, including pain, such as neuropathic pain and migraine, psychiatric diseases, such as anxiety disorder and schizophrenia, urinary incontinence, and neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. Also disclosed are methods for preparing the thienopyrimidinone derivatives, and pharmaceutical compositions containing the thienopyrimidinone derivatives as active ingredients.

Thienopyrimidinone derivatives as mGluR1 antagonists

The present invention relates to a 6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane derivatives useful as calcium channel blockers, pharmaceutically acceptable salts thereof and medical use of the calcium channel inhibiting effect of the compounds for treatment of diseases.

6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane compounds as calcium channel inhibitors

Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof

Provided are a novel 1,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one compound, a pharmaceutically acceptable salt compound thereof, a method for preparing the compound, and an anticancer pharmaceutical composition including the compound as an effective ingredient.

1,6-disubstituted-3-amino-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-C]pyridin-7-one compounds and preparation thereof

The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof

Disclosed are isoindolinone derivatives, represented by Chemical Formula 1, having inhibitory activity against T-type calcium channels, pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an active ingredient. 

Isoindolinone derivatives having inhibitory activity against T-type calcium channel and method for preparation thereof

Disclosed herein are a new phenylacetate derivative represented by Chemical Formula 1 or pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for prevention or treatment of diseases induced by the activation of T-type calcium ion channels containing the same. The composition containing the phenylacetate derivative according to the present invention effectively inhibits the activation of T-type calcium ion channels and may be useful in the prevention or treatment of diseases such as hypertension, cancer, epilepsy, and neurogenic pains induced by the activation of T-type calcium ion channels. 

Phenylacetate derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for prevention or treatment of diseases induced by activation of T-type calcium ion channel containing the same as an active ingredient

The present invention relates to 1,3-dioxoisoindole derivatives of Formula (1) or pharmaceutically acceptable salts thereof, a preparation method thereof and use thereof as a T-type calcium channel antagonist, based on the fact that 1,3-dioxoisoindole derivatives of Formula (1) show selective antagonistic activity against T-type calcium channel, thus being effective in treating brain diseases, cardiac diseases and neurogenic pains: wherein Ris a phenyl or a benzyl group, optionally substituted with a moiety selected from the group consisting of a halogen atom, a C-Calkoxy, a C-Calkyl, and a cyano group; Ris a heterocyclic group selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl, and piperazinyl groups, wherein the heterocyclic group is optionally substituted with a C-Calkyl group; and n is 1 or 2.

1,3-dioxoisoindole derivatives having selective antagonism of T-type calcium channel

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Seoul, South Korea

Seon Hee Seo