Korea Research Institute of Bioscience and Biotechnology

Y-Biologics Inc.

Metabolic Engineering Laboratories Co., Ltd.

Seoul National University

Seon Ha Yun

Young Woo Park

Seok Ho Yoo

Myeoung Hee Jang

Eun Young Lee

Dong Hee Lee

Hee Chan Kim

Bum-chan Park

Eun Bong Lee

Dong Jin Kim

Hye Nan Kim

Ki Won Jo

Seil Jang

Hyun Ju Lee

Kyu Won Cho

Yeong Wook Song

Chan Woong Park

Mi Ra Park

Ki Chul Shin

Heun-Soo Kang

So-Hyun Park

Kyung Jin Kim

Ke Se Lee

The present invention relates to a TNF-&#x3b1; (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG format. Specifically, it was verified that an antibody, in which scFv having a heavy chain variable domain and a light chain variable domain of the CXCL10 specific antibody links to the C-terminus of the heavy chain constant domain of the TNF-&#x3b1; specific antibody, is a bispecific antibody that effectively binds to both TNF-&#x3b1; and CXCL10, and thus the antibody can be useful as a double targeting antibody capable of identifying TNF-&#x3b1;/CXCL10. A composition of the present invention comprises a TNF-&#x3b1;/CXCL-10 double targeting antibody which effectively binds to both TNF-&#x3b1; and CXCL10. The double targeting antibody of the present invention has excellent TNF-&#x3b1; inhibitory activity and osteoclast differentiation inhibitory activity compared with the TNF-&#x3b1; or CXCL10 single targeting antibody. The composition of the present invention can be used in preventing or treating immunological disease.

Anti-TNF-&#x3b1;/CXCL10 double-targeting antibody and use thereof

Disclosed are a human antibody comprising a human complementarity-determining region (CDR), which binds specifically to c-Met, and a framework region (FR), a polynucleotide encoding the human antibody, an expression vector comprising the polynucleotide, a transformant transformed with the expression vector, a method of producing the human antibody B7 by culturing the transformant, a wound healing composition comprising the human antibody as an active ingredient, a cell regeneration composition comprising the antibody as an active ingredient, and a drug conjugate comprising a drug linked to the human antibody. The c-Met-specific human antibody can function as an HGF mimic that can be used as a wound healing composition. The antibody can be widely used to determine the treatment and prognosis of various diseases, including neuronal infarction, progressive nephropathy, liver cirrhosis, lung fibrosis, kidney injury, liver injury, lung injury, and ulcerative wounds, which are treated by activation of HGF or c-Met.

Anti-c-Met antibody having HGF activity and use thereof

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Daejeon, South Korea

Seon Ha Yun