Il Dong Pharmaceutical Co., Ltd.

Seolhee Lee

Jung Woo Lee

Gunhee Kim

Jin Hee Lee

Joontae Park

Kyung Mi An

Te-ik Sohn

Changmok Oh

Yearin Jun

Jungho Kim

Hongchul Yoon

Myongjae Lee

Jongmin Yoon

Jaeeun Ryu

Jooyun Lee

Dami Lim

Jinsun Kwon

Ilji Jeong

Kyeong-A Kim

The present disclosure provides CFTR modulator and phosphodiesterase 4 (PDE4) inhibitor compounds of the formula (Ia): and compositions including said compounds. The compounds can provide functionality for modulating CFTR, methods for treating an eye disease or disorder, and methods for treating CFTR-related indications. The present disclosure also provides methods of using said compounds and compositions for inhibiting PDE4 in a biological system or biological sample, for treating an inflammatory disease or disorder, and for treating other PDE4-related indications. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.

Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators

Growing community of inventors

Hwaseong-si, South Korea

Seolhee Lee