Samsung Fine Chemicals Co., Ltd.

Seok Soo Kim

Ung-Jin Kim

Hee Hwang

Jung Ho So

Il Yong Lee

Sang Ku Lee

Kyoung In Yun

Myung Seung Cho

Hee Won Hwang

Yong Sung Jang

The present invention relates to a process of preparing hydroxyalkyl cellulose derivatives having improved enzymatic resistance. In particular, the present invention relates to a process of preparing hydroxyalkyl cellulose derivatives by reacting cellulose and ethylene oxide in the presence of alkali metal hydroxide, wherein the reaction between cellulose and ethylene oxide is performed in the presence of isopropyl alcohol azeotropic solvent in a horizontally agitated reactor, wherein the ethylene oxide is supplied via two steps, thus resulting in a two-step reaction, and the amount of alkali metal hydroxide remaining after the first reaction is controlled, thereby enabling to provide hydroxyalkyl cellulose derivatives having improved enzymatic resistance and turbidity and to remarkably decrease the solvent usage to have economical and environmental advantages.

Method for preparation of high enzymatic resistance hydroxyalkylcellulose derivatives

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Daejeon, South Korea

Seok Soo Kim