Five Eleven Pharma Inc.

University of Pennsylvania

Seok Rye Choi

Hank F Kung

Zhihao Zha

Zehui Wu

Karl Ploessl

Futao Liu

Chyng-Yann Shiue

Karl Plössl

Shunichi Oya

Grace G Shiue

Ping Fang

The present invention relates to deuterated compounds according to Formula I-A, Formula II-A, Formula II-D, and Formula III-A. These compounds can be used as PET imaging agents for evaluating Parkinson's Disease, Alzheimer Disease, and for determining specific serotonin reuptake inhibitor (SSRIi) activity for treatment of depression. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I-A, Formulae II-A, Formula II-D, or Formula III-A, or a pharmaceutically acceptable salt thereof.

Deuterium substituted positron emission tomography (PET) imaging agents and their pharmacological application

The present invention relates to compounds according to Formula I and Formula IV. These compounds display very good binding affinities to the PSMA binding sites. They can be labeled with [Ga]GaClwith high yields and excellent radiochemical purity. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I or Formula IV, or a pharmaceutically acceptable salt thereof.

Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy

The present invention relates to compounds according to Formula I or Formula II, which are potential bone imaging agents. Certain compounds labeled withGa displayed excellent bone uptake and retention. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I or Formula II or a pharmaceutically acceptable salt thereof. 

HBED-bisphosphonates, radiometal conjugates and their use as theranostic agents

This invention relates to novel fluorinated phenyl thiphenyl (also named diarylsulfide) derivatives and their use in Positron Emission Tomagraphy (PET) imaging of Serotonin Transporters (SERTS). The present invention also provides diagnostic compositions comprising the novel compounds of the present invention, and a pharmaceutically acceptable carrier or diluent. The invention further provides a method of imaging SERTS, comprising introducing into a patient a detectable quantity of a labeled compound of the present invetion, or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.

Fluorinated phenyl thiophenyl derivatives and their use for imaging serotonin transporters

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Aston, PA, United States of America

Seok Rye Choi