Purdue Research Foundation

Seok-Hee Hyun

David H Thompson

Kyle J Wright

Scott Charles Bolton

Christopher Benjamin

Christopher Collins

Yawo Mondjinou

Methods of using grids in connection with suitable microscopy techniques, such as for determining the structure of target compounds including proteins, are disclosed. Said grid comprising a coating modified with one or more capture agents and a deactivating agent.

Grid coatings for capture of proteins and other compounds

Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes of the various embodiments of the present invention.

Polyrotaxanes bearing mixed cyclodextrin species and uses thereof

Grids comprising a coating modified with one or more capture agents and a deactivating agent are disclosed. Methods of using such grids in connection with suitable microscopy techniques, such as for determining the structure of target compounds including proteins, are also disclosed.

A polyrotaxane containing an affinity binding group has been designed and prepared. The polyrotaxane of the invention can be used for characterization and determination of the three-dimensional structures of biological molecules, such as proteins.

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West Lafayette, IN, United States of America

Seok-Hee Hyun