Other

Korea Advanced Institute of Science and Technology

Yonsei University

National Cancer Center

Immunomet Therapeutics Inc.

Seok Gu Kang

Jong Hee Chang

Ji Hyun Lee

Sung Wuk Kim

Sang Hoon Kim

Jung Nyoung Heo

Junseong Park

Se Hoon Kim

Hong Woo Kim

Soo Youl Kim

Jae Ho Cheong

Jeong Ho Lee

Joo Ho Lee

Chulmin Joo

Yong Min Huh

Jeong Eun Lee

Sang Hee Yoo

Jin Suck Suh

Seung Jae Oh

Soon Im Lee

Yun Hee Jo

Jin Kyoung Shim

Eui Hyun Kim

Youngbin Ji

Jun Jeong Choi

The present invention relates to a brain tumor animal model that directly reflects the phenomenon in a human patient and a method of preparing the same, and more specifically, a brain tumor animal model that mutations are introduced into p53, Pten, and EGFR genes, a screening method of a therapeutic agent for a brain tumor using the animal model, and a preparing method thereof.

Animal model of brain tumor and manufacturing method of animal model

A method and an apparatus for diagnosing a brain tumor in real-time are disclosed. A method for detecting a brain tumor in real-time can comprise the steps of: generating, by a probe, a plurality of input signals and transferring the same to a target detection region which is estimated to be the location of a brain tumor; receiving, by the probe, a plurality of reflection signals on the basis of a plurality of input signals; and detecting, by the probe, a plurality of the received reflection signals, wherein a plurality of the input signals comprise a terahertz signal, an optical coherence tomography (OCT) signal, and a Raman signal, and a plurality of the reflection signals can be used for generating a plurality of image information for detecting the location of a brain tumor; and an apparatus for diagnosing a brain tumor in vitro and in real-time, can be used to diagnose, in real-time, a brain tumor specimen, which is extracted from the brain.

Multiple optical fusion-image based method and apparatus for diagnosing brain tumor in real-time

The present invention relates to a pharmaceutical composition for inhibiting growth of cancer stem cells, containing an aldehyde inhibitor and a biguanide-based compound. The pharmaceutical composition according to the present invention contains a combination of an aldehyde inhibitor and a biguanide-based compound, which can effectively inhibit the growth of cancer stem cells such as neurospheres and can also inhibit the proliferation, invasion and metastasis of cancer cells, thereby preventing and/or treating cancer such as brain cancer.

Pharmaceutical composition for inhibiting growth of cancer stem cells, containing aldehyde inhibitor and biguanide-based compound

The present invention provides novel uses of a biguanide derivative for preventing or treating glioblastoma. The compound of Formula 1 and its pharmaceutically acceptable salts can be used for preventing and treating glioblastoma. Further, the combined treatment of the compound of Formula 1 and temozolomide can provide superior effects compared to the administration of the compound of Formula 1 alone or temozolomide alone.

Pharmaceutical composition comprising a biguanide derivative as an active ingredient for preventing or treating glioblastoma

Growing community of inventors

Suwon-si, South Korea

Seok Gu Kang