Polytherics Limited

Senzhi Zhao

Fu-An Kang

Nareshkumar Jain

Sanjeevani Ghone

Sean Wesley Smith

Ian Glassford

Sylvia J Degrado

Provided herein are novel maytansinoid compounds of general formula I. Also provided herein are conjugates comprising the compounds linked to a binding protein via a linker, and conjugating reagents comprising the compounds attached via a linker to at least one functional group capable of reacting with a binding protein. Also provided herein are pharmaceutical compositions comprising the compounds and conjugates, therapeutic methods and uses involving the compounds and conjugates, for example in cancer therapy, and novel synthetic processes.

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Bensalem, PA, United States of America

Senzhi Zhao