The Salk Institute for Biological Studies

Research Development Foundation

Joint Center for Biosciences

Senyon Choe

Tarmo Roosild

Jason Greenwald

Ronald Mark Evans

Michael Downes

Annette R Atkins

Wylie Walker Vale, Jr

Jae Myoung Suh

Peter C Gray

Craig A Harrison

Roland Riek

Wolfgang Fischer

George Allendorph

Witek Kwiatkowski

Michael J Isaacs

Scott D Pegan

Paul A Slesinger

Prafulla Aryal

Mike Isaacs

The present disclosure provides chimeric proteins having an N-terminus coupled to a C-terminus, wherein the N-terminus comprises an N-terminal portion of fibroblast growth factor (FGF) 2 and the C-terminus comprises a portion of an FGF1 protein, wherein the chimeric protein comprises at least 95% sequence identity to SEQ ID NO: 9, 10, 11, 12 or 13. Also provided are nucleic acid molecules that encode such proteins, and vectors and cells that include such nucleic acids. Methods of using the disclosed molecules to reduce blood glucose levels are also provided.

Chimeric fibroblast growth factor (FGF) 2/FGF1 peptides and methods of use

The present disclosure relates to chimeric polypeptide having TGF-beta activity, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.

Designer ligands of TGF-&#x3b2; superfamily

A class of integral membrane proteins, referred to as Mistic polypeptides, their variants, fusion proteins including a Mistic polypeptide domain, and nucleic acid molecules encoding Mistic polypeptides and Mistic fusion proteins are disclosed herein. Also described are methods of using Mistic polypeptides and Mistic fusion proteins to produce and/or isolate recombinant proteins (including without limitation classes of eukaryotic proteins that have previously been intractable to recombinant bacterial expression, such as, eukaryotic integral membrane proteins).

Compositions and methods for producing recombinant proteins

Provided is a three-dimensional structure of an alcohol bound to an alcohol-binding site of an inwardly rectifying potassium (Kir) channel, Kir channel alcohol modulators and methods for identifying Kir channel modulators.

Kir channel modulators

Members of the TGF-&#x3b2; superfamily control many physiologic and pathophysiologic processes in multiple tissues and signal via type II and type I receptor serine kinases. Type II activin receptors are promiscuous and known to bind 12 TGF-&#x3b2; ligands including activins, myostatin, BMPs and nodal. Methods are described for the screening and identification of antagonist for TGF-&#x3b2; superfamily members, in particular activin-A antagonist.

Activin-A mutants

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Solana Beach, CA, United States of America

Senyon Choe