Orchid Chemicals & Pharmaceuticals Limited

Allecra Therapeutics Gmbh

Senthilkumar Udayampalayam Palanisamy

Maneesh Paul-Satyaseela

Sureshkumar Kanagaraj

Sivakumar Balasubramanian

Mohan Singaravel

Sriram K Rajagopal

Gopalan Balasubramanian

Shridhar Narayanan

Andrew Gnanaprakasam

Hariharan Periasamy

Sathishkumar Devarajan

Shakti Singh Solanki

Venkatasubramanian Hariharan

Mukut Gohain

Panchapakesan Ganapathy

Vignesh Babu Heeralal

Meenakshi Sundaram Soma Sundaram

Manimaran Arasappan

Senthilnathan Manickam

Aravind Appu

Described herein are compounds and their use in the treatment of infections. The compound of formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and pharmaceutical compositions described herein are also useful as &#x3b2;-lactamase inhibitors, which restore or enhance the antibiotic spectrum of a suitable antibiotic agent. The compounds of formula (I) act as inhibitors of &#x3b2;-lactamases. These compounds restore/potentiate the activities of &#x3b2;-lactam antibiotics against carbapenemases. These compounds find use in diagnostic method for detecting &#x3b2;-lactamases. Formula (I) 

Compounds and their use

The present invention relates to novel polymorph of Ceftiofur sodium as a crystalline product. The present invention also provides a process for the preparation of novel polymorphs of crystalline Ceftiofur sodium of formula (I). 

Crystalline sodium salt of cephalosporin antibiotic

Polymorphs of Ceftiofur sodium as a crystalline product and a process for the preparation of polymorphs of crystalline Ceftiofur sodium of formula (I).

An improved process for the preparation of carbapenem antibiotic of formula (I) or its hydrate is provided. 

Process for the preparation of carbapenem antibiotic

Novel 2-substituted methyl penam derivatives include the formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their solvates, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them; wherein A=C or N; Het is a three- to seven-membered heterocyclic ring; Rrepresents carboxylate anion, or &#x2014;COORwhere Rrepresents hydrogen, carboxylic acid protecting group or a pharmaceutically acceptable salt; Rand Rmay be same or different and independently represent hydrogen, halogen, amino, alkyl, protected amino, optionally substituted alkyl, alkenyl, alkynyl and the like; R represents substituted or unsubstituted alkyl, alkenyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heterocyclylalkyl.

2-substituted methyl penam derivatives

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Chennai, India

Senthilkumar Udayampalayam Palanisamy