Aurobindo Pharma Limited

Senthil Kumar Natarajan

Sivakumaran Meenakshisunderam

Ramesh Dandala

Shankar Reddy Budidet

Somappa Somannavar Yallappa

Brajesh Kumar Sinha

Sankar Reddy Budidet

Venkata Kishore Gowrabathina

An improved process for the preparation of (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole of Formula I, (I) with high enantiomeric excess from racemic mixture. 

Process for preparing an optically active proton pump inhibitor

The present invention provides a method for the preparation of N-(1-oxopentyl)-N-[[2'-(1H-tetra-zol-5-yl)[1,1&#x2032;-biphenyl]-4-yl]methyl]-L-valine (Valsartan) which comprises; treating N-[[2&#x2032;-(1-triphenylmethyl-tetra-zol-5-yl)biphenyl-4-yl]methyl]-L-valine methyl ester (X) with oxalic acid or its hydrates in a solvent to produce N-[[2&#x2032;-(1-triph-enylmethyl-tetrazol-5-yl)biphenyl-4-yl]methy]-L-valine methyl ester oxalate (Xa) and treating the compound (Xa) with a base in a solvent followed by reacting with valeryl chloride in presence of base in a solvent to produce N-[[2&#x2032;-(1-triphenylmethyl-tetra-zol-5-yl)[1,1&#x2032;biphenyl]-4-yl]methyl]-N-valeryl-L-valine methyl ester (XI), de-protecting the compound (XI) using anhydrous acidic conditions to produce N-(1-oxopentyl)-N-[[2&#x2032;-(1-H-tetrazol-5-yl)[1,1&#x2032;biphenyl]-4-yl]methyl-L-valine methyl ester (V) followed by treating with base in a solvent to produce Valsartan.

Process for the preparation of angiotensin II antagonist

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Hyderabad Telangana, India

Senthil Kumar Natarajan