Chinese Academy of Sciences

Suzhou Suplead Life Sciences Co., Ltd.

Suzhou Institute of Materia Medica

Senhao Xiao

Hualiang Jiang

Cheng Luo

Bing Zhou

Yaxi Yang

Shijie Chen

Gang Qiao

Hong Ding

Xinjun Wang

Zizhou Li

Lianghe Mei

Wenchao Lu

Shili Wan

Rukang Zhang

Disclosed is a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by the general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereoisomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising same and use thereof in the treatment of various HAT-related diseases or conditions.

Histone acetyltransferase (HAT) inhibitor and use thereof

The present invention relates to a bromodomain inhibitor. Provided are a compound represented by general formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, atropisomer, racemate, polymorph, solvate, or isotopically labeled compound (including deuterium substitution) thereof, a preparation method of the same, a pharmaceutical composition comprising the same, and a pharmaceutical use thereof. 

Bromodomain inhibitor compound and use thereof

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Shanghai, China

Senhao Xiao