Marengo Therapeutics, Inc.

Seng-Lai Tan

Andreas Loew

Brian Edward Vash

Jonathan Hsu

Dilini Charmain Gunasekera

Sangeetha Sagar Palakurthi

Madan Katragadda

Stephanie J Maiocco

Nidhi Malhotra

Peter Marek

Gurkan Guntas

Multifunctional molecules that include i) an antigen binding domain that binds to a T cell receptor beta chain constant domain 1 or T cell receptor beta chain constant domain 2; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule or cytokine inhibitor molecule; (iv) a death receptor signal enhancer; and/or (v) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Multifunctional molecules that bind to T cell related cancer cells and uses thereof

The disclosure provides antibody molecules that bind to TCR Vβ regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Anti-TCR antibody molecules and uses thereof

Method of treating solid cancers with bispecific interleukin-anti-TCRß molecules

Growing community of inventors

Sudbury, MA, United States of America

Seng-Lai Tan