Vertex Pharmaceuticals, Inc.

Biomatrica, Inc.

Senait G Ghirmai

Mark Thomas Miller

Jinglan Zhou

Andreas Peter Termin

Sara Sabina Hadida Ruah

Jason McCartney

Corey Don Anderson

Peter Grootenhuis

Thomas Cleveland

Haripada Khatuya

Bryan A Frieman

Timothy Richard Coon

Johnny Uy

Prasuna Paraselli

Fabrice Pierre

Jeremy J Clemens

Rolf Muller

Brett Bradley Busch

Weichao George Chen

Alexander Russell Abela

Scott E Whitney

Sara E Swift

Clara Kuang-Ju Hsia

Ping Kang

Anton V Gulevich

Carl V Vogel

Steven P Wilkinson

Vasco Liberal

Stephanie De Los Rios

Jason Mccartney

Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Modulators of Cystic Fibrosis Transmembrane Conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulators

Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulators

Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period.

Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures

Described herein are stabilized polymerase compositions comprising a polymerase and an polymerase stabilizing agent, such as a non-detergent zwitterionic stabilizer or a cationic ester disclosed, for use in nucleic acid amplification or nucleic acid sequencing. Compositions are provided for the stabilization of one or more polymerases in a single stabilized liquid formulation. Also disclosed are methods for making and using stabilized polymerase compositions and kits for nucleic acid amplification and sequencing comprising the stabilized polymerase compositions provided.

Formulations and methods for stabilizing PCR reagents

Growing community of inventors

San Diego, CA, United States of America

Senait G Ghirmai