Ajinomoto Co., Ltd.

Ea Pharma Co., Ltd.

Sen Takeshita

Satoru Okamoto

Yusuke Amino

Yuzuru Eto

Naoyuki Fukuchi

Naoyuki Yamada

Takao Ikenoue

Masaru Takayanagi

Wataru Miyanaga

Yumiko Fukuda

Naoko Arashida

Takeaki Ohsu

Naohiro Miyamura

Hiroaki Nagasaki

Tomohiko Yamanaka

Tadakiyo Nakagawa

Munetaka Tokumasu

Kaori Kobayashi

Tomomi Yoshida

Kayo Matsumoto

Hiroki Inoue

A method of screening a compound having a hypoglycemic effect (hereinafter referred to as 'hypoglycemic compound'), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the &#x3b2; subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the &#x3b2; subunit of a trimeric GTP-binding protein, as the active ingredient, etc.

Remedy for diabetes

The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.

Kokumi-imparting agent

Provided is a compound represented by the following general formula (I), or a pharmaceutically acceptable salt thereof. This novel compound has a glycogen-synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe.  In the formula, Ar is an aromatic carbocyclic ring or a heterocyclic ring; and Aris represented by any one of the following rings and the like. 

Pharmaceutical composition for treating diabetes

A calcium receptor activator and compositions containing at least one of the following: &#x3b3;-Glu-Cys-Gly, &#x3b3;-Glu-Cys(SNO)-Gly, &#x3b3;-Glu-Ala, &#x3b3;-Glu-Gly, &#x3b3;-Glu-Cys, &#x3b3;-Glu-Met, &#x3b3;-Glu-Thr, &#x3b3;-Glu-Val, &#x3b3;-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, D-Cys, &#x3b3;-Glu-Met(O), &#x3b3;-Glu-Val-Val, &#x3b3;-Glu-Val-Glu, &#x3b3;-Glu-Val-Lys, &#x3b3;-Glu-&#x3b3;-Glu-Val, &#x3b3;-Glu-Val-NH, &#x3b3;-Glu-Val-ol, &#x3b3;-Glu-Ser, &#x3b3;-Glu-Tau, &#x3b3;-Glu-Cys(S-Me)(O), &#x3b3;-Glu-Leu, &#x3b3;-Glu-Ile, &#x3b3;-Glu-t-Leu, &#x3b3;-Glu-Cys(S-allyl)-Gly, &#x3b3;-Glu-Gly-Gly, &#x3b3;-Glu-Val-Phe, &#x3b3;-Glu-Val-Ser, &#x3b3;-Glu-Val-Pro, &#x3b3;-Glu-Val-Arg, &#x3b3;-Glu-Val-Asp, &#x3b3;-Glu-Val-Met, &#x3b3;-Glu-Val-Thr, &#x3b3;-Glu-Val-His, &#x3b3;-Glu-Val-Asn, &#x3b3;-Glu-Val-Gln, &#x3b3;-Glu-Val-Cys, &#x3b3;-Glu-Val-Orn, &#x3b3;-Glu-Ser-Gly, &#x3b3;-Glu-Cys(S-Me), &#x3b3;-Glu-Abu-Gly, &#x3b3;-Glu-Cys(S-Me)-Gly, and &#x3b3;-Glu-Val-Gly.

Calcium receptor activator

Growing community of inventors

Kawasaki, Japan

Sen Takeshita