Galileo Pharmaceuticals, Inc.

Monsanto Technology LLC

Johnson & Johnson Consumer Companies, Inc.

Monsanto Company

Carnegie Institution of Washington

Calgene Corporation

Edison Pharmaceuticals, Inc.

Sekhar S Boddupalli

Bing Wang

Guy M Miller

Lesley A Brown

Ganesh M Kishore

Stephen F Flaim

Gail Walkinshaw

Shaukat H Rangwala

Wei Zhang

Jian Chen

Khalid Mahmood

Jiangao Song

Claude Saliou

Chris Somerville

Frank Van De Loo

Mylavarapu Venkatramesh

Pierre Broun

Ughetta Del Balzo

Michael Anthonavage

Darlene M Dreon

Stephen D Phinney

Kelly Huang

B Ganesh Bhat

Peggy Beinlich

David Richard Corbin

Michael W Lassner

Yong-Kang Zhang

Balasulojini Karunanandaa

Christine K Shewmaker

Jingdong Liu

Donald R James

Xianfeng Li

Kathryn Dennis Lardizabal

Sylvain Gilat

Xianming Jin

Mylavaraapu Venkatramesh

Robert J Grebenok

Barkur G Bhat

Steven Bobzin

Arkadij M Elizarov

This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty acids in transgenic plants. In addition, the use of genes encoding fatty acid hydroxylases or desaturases to alter the level of lipid fatty acid unsaturation in transgenic plants is described.

Production of hydroxylated fatty acids in genetically modified plants

The invention relates to a method of treating with furanone derivatives and the pharmaceutically acceptable salts thereof, one or more conditions of the skin, in particular regulating skin condition, regulating signs of skin aging, treating a number of conditions such as contact dermatitis, skin irritation, rosacea, acne, psoriasis, and preventing and protecting skin tissue against age-related damage or damage resulting from insults such as harmful (UV) radiation or environmental pollution, stress and fatigue.

Furanone derivatives

The present invention features composition comprising a chalcone and the use thereof for treating acne and reducing the appearance of oil or pores on the skin, hair and scalp.

Compositions containing chalcones and use thereof

Provided are recombinant constructs comprising DNA sequences encoding enzymes effective in altering the biosynthesis and accumulation of sterol compounds and tocopherols in transgenic plants. Also provided are methods of using such constructs to produce transgenic plants, seeds of which contain elevated levels of sitostanol and/or sitostanol esters, and &#x3b1;-tocopherol, as well as reduced levels of campesterol and campestanol and their corresponding esters. These seeds also contain the novel sterol brassicastanol. Oil obtained from seeds of such transgenic plants is also provided. This oil can be used to prepare food and pharmaceutical compositions effective in lowering the level of low density lipoprotein cholesterol in blood serum. In addition, novel DNA sequences encoding plant steroid 5&#x3b1;-reductases are also disclosed.

Transgenic plants containing altered levels of sterol compounds and tocopherols

The present invention is in the field of plant biochemistry. More specifically the invention relates to nucleic acid sequences from plant cells, in particular, nucleic acid sequences from maize and soybean associated with the tocopherol synthesis pathway enzymes. The invention encompasses nucleic acid molecules that encode proteins and fragments of proteins. In addition, the invention also encompasses proteins and fragments of proteins so encoded and antibodies capable of binding these proteins or fragments. The invention also relates to methods of using the nucleic acid molecules, proteins and fragments of proteins and antibodies, for example for genome mapping, gene identification and analysis, plant breeding, preparation of constructs for use in plant gene expression and transgenic plants.

Nucleic acid molecules associated with the tocopherol pathway

Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.

Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods

The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

Chroman derivatives

The present invention features composition comprising an extract of aand the use thereof for treating acne and reducing the appearance of oil or pores on the skin, hair and scalp.

Compositions containing an extract of a primula denticulata and use thereof

The present invention provides non-alpha-tocopherol enriched tocopherol compositions and non-alpha-tocopherol metabolite enriched compositions for use in the reduction of inflammatory markers associated with inflammation such as C-reactive protein.

Tocopherol enriched compositions and amelioration of inflammatory symptoms

Non-alpha-tocopherol enriched tocopherol compositions and non-alpha metabolite enriched compositions are disclosed for use in the reduction of the inflammatory marker IL-6.

Tocopherol enriched compositions for reducing IL6 levels

Certain benzofuran derivatives are useful in the treatment of certain ischemic or inflammatory conditions, as well as neuroinflammation, neurodegeneration or degenerative diseases in which mitochondrial dysfunction leads to tissue degeneration. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

Benzofuran derivatives

The present invention provides method for the treatment of a symptom of neuronal damage associated with cerebral ischemia comprising administering gamma-, beta-, or delta-tocopherol enriched tocopherol compositions.

Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols

Methods are provided for producing plants and seeds having altered carotenoid, fatty acid and tocopherol compositions. The methods find particular use in increasing the carotenoid and tocopherol levels in oilseed plants, and in providing desirable high oleic acid seed oils.

Methods for producing carotenoid compounds, tocopherol compounds, and specialty oils in plant seeds

Growing community of inventors

Manchester, MO, United States of America

Sekhar S Boddupalli