Jeol Ltd.

Tokuyama Corporation

Princeton University

Joel Ltd.

Other

Tokyo University of Science Foundation

Seketsu Fukuzawa

Masaki Takiwaki

Daniel E Kahne

Min Ge

Christopher Thompson

Misao Matsushige

Robert Kerns

Makoto Satou

Koji Takahashi

Yoshiyuki Ito

Shin Watanabe

Kentaro Abe

Tatsuya Higashi

Shoujiro Ogawa

Yoshiyuki Itoh

Masahiko Seki

Yoshikuni Kikutani

Kiyotaka Fujino

Taku Yoshiya

Masayoshi Mochizuki

Shugo Tsuda

Provided is a phosphonium compound represented by Formula (I): in Formula (I), R, R, and Rare independently from each other, an alkyl group or an aryl group, the alkyl group is a substituted or unsubstituted, linear or branched alkyl group having 1 to 20 carbon atoms or a substituted or unsubstituted cyclic alkyl group having 5 to 20 carbon atoms, the aryl group is a substituted or unsubstituted aryl group having 6 to 20 carbon atoms; X is a reactive group having a hydrazide group, a halide group, a pseudohalide group, or a thioester group; and Yis an anion having a total charge of −1, or Yis absence.

Phosphonium compound, reagent kit for derivatization, mass spectrometric method, and method for producing phosphonium compound

Provided are a stable triazolinedione adduct, a method for producing the same, a method for producing an ene compound, and a method for analyzing an ene compound. A triazolinedione adduct that is stable until the time of use and can be reacted while reverting to a triazolinedione compound at the time of use. Specifically, a triazolinedione adduct represented by formula (1). (In the formula, Ris an organic group, and A is a fused ring of three or more rings including at least one aromatic ring.)

Triazolinedione adduct, method for producing triazolinedione adduct, method for producing ene compound, and method for analyzing ene compound

A standard calibration solution includes water, a non-alcoholic solvent that is mixed with water, and a steroid hormone, and a content of the non-alcoholic solvent is 10% by volume or more and 50% by volume or less. The standard calibration solution is used for quantitative measurement using a mass spectrometry device.

Standard calibration solution

Provided is a method for analyzing a diene compound including: a triazolinedione adduct heating step of heating a triazolinedione adduct to produce a triazolinedione compound; an ene compound formation step of reacting the triazolinedione compound with a diene compound to obtain an ene compound; and an ene compound analysis step of analyzing the ene compound to quantitative determine the diene compound. Also provided is a method for producing an ene compound, including: a triazolinedione adduct heating step of heating a triazolinedione adduct to produce a triazolinedione compound; and an ene compound formation step of reacting the triazolinedione compound with a diene compound to obtain an ene compound.

Analysis method of diene compound

A compound represented by Chemical formula 1: wherein n is an integer of 2 or more, is provided. Also provided is a derivatization reagent for derivatizing a diene-containing compound, including a compound represented by Chemical formula 1. Further provided is a synthesis method for a compound, including a nucleophilic substitution reaction between an aryl halide and a heterocyclic amine compound being saturated, the compound being represented by Chemical formula 1.

Compound, derivatization reagent, and method for synthesizing compound

Provided is a method for industrially producing a triazolidinedione compound at a high purity and a high yield. A precipitation step for preparing a solution that contains a triazolidinedione compound represented by formula (1) and precipitating the triazolidinedione compound therefrom is performed. In this step, the pH of the solution is adjusted to 3.0 to 8.5 and the solution is prepared so as to contain 3-15 parts by volume of solvents for 1 part by mass of the triazolidinedione compound. (In the formula, Ris a substituted or unsubstituted amino group-bearing organic group.) 

Method for producing triazolidinedione compound

Provided is a method for producing a high-purity, high-quality semicarbazide compound at a high yield by a simple method. The semicarbazide compound is recrystallized by a solvent containing a halogenated hydrocarbon. Dichloromethane is preferred as the halogenated hydrocarbon.

Method for producing semicarbazide compound

A glycopeptide of the formula A-A-A-A-A-A-A, in which each dash represents a covalent bond; wherein Acomprises a modified or unmodified &#x3b1;-amino acid residue, alkyl, aryl, aralkyl, alkanoyl, aroyl, aralkanoyl, heterocyclic, heterocyclic-carbonyl, heterocyclic-alkyl, heterocyclic-alkyl-carbonyl, alkylsulfonyl, arylsulfonyl, guanidinyl, carbamoyl, or xanthyl; wherein each of Ato Acomprises a modified or unmodified &#x3b1;-amino acid residue, whereby (i) Ais linked to an amino group on A, (ii) each of A, Aand Abears an aromatic side chain, which aromatic side chains are cross-linked together by two or more covalent bonds, and (iii) Abears a terminal carboxyl, ester, amide, or N-substituted amide group; A chemical library comprising a plurality of the glycopeptides of the invention. A method for preparing a glycopeptide by glycosylation of an aglycone derived from a glycopeptide antibiotic. A method for preparing a glycopeptide by preparing a pseudoaglycone from a glycopeptide antibiotic and glycosylating the pseudoaglycone.

Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same

Methods for preparing a glycopeptide are disclosed. The methods comprise the steps of selecting a protected glycopeptide of the formula A-A-A-A-A-A-A, wherein the groups Ato Acomprise the heptapeptide structure of naturally occurring vancomycin; at least Ais linked to a glycosidic group which has a hexose residue linked to A; and the protected glycopeptide has no free amino or carboxyl groups and has a free primary hydroxyl group only at the 6-position of said hexose residue. The protected glycopeptide is contacted with a compound of the formula ArSOG where Ar is an aryl group and G is a leaving group under conditions effective to allow reaction of said free primary hydroxyl group to form a glycopeptide sulfonate ester; and the glycopeptide sulfonate ester is contacted with a nucleophile under conditions effective to allow displacement of a sulfonate group to produce a substituted glycopeptide.

Glycopeptide antibiotics, combinational libraries of glycopeptide antibiotics and methods of producing same

Growing community of inventors

Tokyo, Japan

Seketsu Fukuzawa