Alcolear Limited

The Hong Kong University of Science and Technology

Sek Lun Law

Bing Lou Wong

Hong Xue

A composition includes two exogenous enzymes from animals for consumption by human beings to prevent, treat and/or alleviate veisalgia and/or symptoms associated therewith arising from or caused by consumption or spontaneous production of alcohol through a dual-enzyme based breakdown of the alcohol, wherein a first enzyme of the two exogenous enzymes is capable of converting alcohol into a first metabolite while a second enzyme thereof is capable of converting the first metabolite into a second metabolite which is excretable to systemic circulation after an oxidation reaction of the alcohol in the presence of the two exogenous enzymes and NAD/NADH, and wherein the first enzyme to the second enzyme is in a molar ratio of 1:3-51 in the composition in order to avoid an elevation in the level of the first metabolite in the human being.

Dual-enzyme composition for preventing, treating and/or alleviating veisalgia and symptoms associated therewith

A composition including two exogenous enzymes from animals for consumption by human being before and/or after consuming alcohol to prevent, treat and/or alleviate veisalgia and/or symptoms associated therewith arising from or caused by excessive consumption of alcohol through a dual-enzyme based breakdown of the excess alcohol is provided, wherein a first enzyme of the two exogenous enzymes is capable of converting alcohol into a first metabolite while a second enzyme thereof is capable of converting the first metabolite into a second metabolite which is excretable to systemic circulation after an oxidation reaction of the alcohol in the presence of the two exogenous enzymes and NAD/NADH; the first enzyme to the second enzyme is in a molar ratio that maintains a ratio between the first and second metabolites in the human being so as to avoid local elevation of the first metabolite in the human being after consumption of excess alcohol.

The present invention is concerned with new, previously unsuggested, therapeutic uses of dl-THP (dl-tetrahydropalmatine) including anxiety disorders, seizures, and status epilepticus.

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Sek Lun Law