Takeda Chemical Industries, Inc.

Seizi Igarasi

Masao Ogawa

Yoshio Yamazaki

Yutaka Miyashiro

Makoto Kida

A matrix comprising a water-insoluble .beta.-1,3-glucan gel in the shape of beads with diameters within the range of about 5 to 1000.mu. is prepared by, for example, dispersing an alkaline aqueous solution of a water-soluble .beta.-1,3-glucan in a water-immiscible organic solvent, and adding an organic acid to the resultant dispersion. The matrix is useful as carrier materials for immobilized enzymes, affinity chromatography, gel filtration, ion exchange and other applications.

Polysaccharide beads

A matrix comprising a water-insoluble .beta.-1,3-glucan gel in the shape of beads with diameters within the range of about 5 to 1000 .mu. is prepared by, for example, dispersing an alkaline aqueous solution of a water-insoluble .beta.-1,3-glucan in a water-immiscible organic solvent, and adding an organic acid to the resultant dispersion. The matrix is useful as carrier materials for immobilized enzymes, affinity chromatography, gel filtration, ion exchange and other applications.

Phosphoric acid esters of xylostasin, an intermediate for the synthesis of antibiotic deoxy-xylostasin or the like, are obtained by contacting xylostasin with cells or cell materials of microorganism belonging to the genus Escherichia or Pseudomonas which is resistant to xylostasin, in the presence of a phosphate donor.

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Ashiya, Japan

Seizi Igarasi