Mitsui Toatsu Chemicals, Incorporated

Mitsui Toatsu Kagaku Kabushiki Kaisha

Mitsui Toatsu Kagaki Kabushiki Kaisha

Mitsui Toatsu Kaguku Kabushiki Kaisha

Seitaro Kajiya

Hiroshi Kawazura

Akira Awaya

Tatsuro Yokoyama

Yutaka Okazaki

Hiroshi Tokuda

Mikio Kumakura

Isao Sakano

Norio Ohto

Takuo Nakano

Kazutoshi Horikomi

Akira Matsubara

Kazuya Sakai

Akira Mizuchi

Hideki Tanada

Hideshi Shimizu

Hajime Iizuka

Kunio Okumura

Junya Fujiwara

Yoshio Shiga

Yasuhiro Takahashi

Kengo Otsuka

Masahiko Maruyama

Makoto Hirayama

Tatsuo Kaiho

Tamotsu Minami

Aminoketone derivative compounds containing a heterocyclic ring bonded to an aminoketone moiety and useful as effective ingredients of centrally acting muscle relaxants and pollakiurea curing agents. (+)3-phenyl-5-[2-(1-pyrrolidinylmethyl)butyryl] isoxazole, which has a more remarkable central muscle relaxant action as compared with its racemic modification, can be effectively separated from the racemic modification using optically active 10-camphorsulfonic acid as the agent for the optical resolution.

Aminoketone derivatives and use thereof

Aminoketone derivative compounds containing a heterocyclic ring bonded to an aminoketone moiety and useful as effective ingredients of centrally acting muscle relaxants and pollakiurea curing agents. (+)3-phenyl-5-[2-(1-pyrrolidinylmethyl)butyryl]isoxazole, which has a more remarkable central muscle relaxant action as compared with its racemic modification, can be effectively separated from the racemic modification using optically active 10-camphorsulfonic acid as the agent for the optical resolution.

Aminoketone derivative and use thereof

Aminoketone derivatives of 1,2-oxazole and use thereof

The present invention relates to a novel (-)-2-pyrazoline compound and therapeutic agents containing the same as an effective ingredient; furthermore, it relates to a method for optically resolving 1-(3-pyridylcarbonyl)-5-methyl-2-pyrazoline.

(-)-2-pyrazoline compounds and therapeutic agent for cerebrovascular

Method of optically resolving

The isoquinoline derivatives represented by the following general formula (I) are useful as cardiotonics having high cardiotonic activity and low toxicity: ##STR1## where R.sub.1 represents a lower C.sub.1 -C.sub.4 alkyl group or cyclopropyl group,

Isoquinoline derivatives

Disclosed are 2-thiazol derivatives having the general formula ##STR1## where R.sub.1 and R.sub.2 independently represent lower alkyl radicals having 1 to 4 carbon atoms and X represents a lower alkyl radical, a lower alkoxy radical, a lower alkoxycarbonyl radical, a halogenoalkoxy radical, a radical of the formula ##STR2## or a radical of the formula ##STR3## Also disclosed are a process for preparing the derivatives and pharmaceutical compositions having immunomodulatory activity which comprise the derivatives as the active ingredient.

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Chigasaki, Japan

Seitaro Kajiya