Ajinomoto Co., Ltd.

Seiko Otsuna

Masaki Kobayashi

Tsuyoshi Nakamatsu

Masakazu Sugimoto

Yasuhiko Yoshihara

Atsushi Hayakawa

Masako Izui

Eiichi Nakano

Yasuhiko Ajinomoto Co Inc Technology Yoshihara

The ability and speed with which a coryneform bacterium can produce L-lysine are improved when the coryneform bacterium contains an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized. This is accomplished by successively enhancing the DNA coding for dihydrodipicolinate reductase, the DNA coding for dihydrodipicolinate synthase, the DNA coding for diaminopimelate decarboxylase, and the DNA coding for diaminopimelate dehydrogenase.

Method of producing L-lysine

The L-lysine-producing ability and the L-lysine-producing speed are improved in a coryneform bacterium harboring an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized, by successively enhancing DNA coding for a dihydrodipicolinate reductase, DNA coding for a dihydrodipicolinate synthase, DNA coding for a diaminopimelate decarboxylase, and DNA coding for a diaminopimelate dehydrogenase.

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Kawasaki, Japan

Seiko Otsuna