Meiji Co., Ltd.

Meiji Dairies Corporation

Seiko Narushima

Masayuki Uchida

Keiko Morikubo

Makoto Yamaguchi

Yoshitaka Nakamura

Shuji Ikegami

Katsunori Kimura

Masaki Terahara

Shinya Nagafuchi

Toshihiro Sashihara

A probioticwas discovered from lactobacilli of thegenus independently isolated from human adult feces. The probioticwas selected from other bacterial strains for: (1) being highly resistant to gastric acid/bile acid; (2) having a high promoting activity on IL-12 production from mouse derived spleen cells and a high Th1/Th2 balance-improving effect; (3) having a high ability to inhibit the production of antigen-specific IgE induced by intraperitoneally administering ovalbumin to BALB/c mice; (4) having a high ability to inhibit the production of antigen-specific IgE induced by orally administering a food antigen to C57BL/6N mice; (5) having a high Natural Killer cell-activating ability; (6) having a high IL-12 production-promoting activity on spleen cells and mesenteric lymph node cells derived from mice immunized with ovalbumin and a high Th1/Th2 balance-improving effect; and (7) having a high ability to suppress eosinophilia induced by a cedar pollen-extracted antigen. This discovery led to the completion of the present invention.

Immune function modulating agents

The present invention relates to a preventive and/or a therapeutic agent for inflammatory bowel diseases containing a fermentation product of a propionic acid bacterium as an active ingredient.

Preventive and/or therapeutic agent for inflammatory bowel diseases

Preventive and/or remedy for inflammatory bowel diseases

Growing community of inventors

Ichikawa, Japan

Seiko Narushima