Daiichi Sankyo Company, Limited

Seiko Nagata

Yasuyuki Ogawa

Keiji Saito

Katsuyoshi Nakajima

Kaori Ito

Toru Taniguchi

Osamu Iwamoto

Nobuya Kurikawa

Eriko Kioi

Makoto Hirasawa

Mitsuhiro Makino

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: A: e.g., Benzene, E: e.g., —CH—, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R, R, R: e.g., a halogen atom, R: e.g., a C1-C6 alkyl group, R: e.g., a hydrogen atom, R, R, R, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, n, n, n: e.g., 1.

Compound having cyclic structure

The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R: a C1-C6 alkyl group or the like, R: a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R, R': a C1-C6 alkyl group or the like].

Griseofulvin compound and pharmaceutical use thereof

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below:A: e.g., Benzene, E: e.g., &#x2014;CH&#x2014;, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R, R, R: e.g., a halogen atom, R: e.g., a C1-C6 alkyl group, R: e.g., a hydrogen atom, R, R, R, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, n, n, n: e.g., 1.

The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R: a C1-C6 alkyl group or the like, R: a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R, R: a C1-C6 alkyl group or the like.

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Shinagawa-ku, Japan

Seiko Nagata