Kyowa Hakko Kogyo Co., Ltd.

Seiko Ando

Keiko Ochiai

Haruhiko Yokoi

Satoshi Nakagawa

Akio Ozaki

Masato Ikeda

Shin-ichi Hashimoto

Yoshiyuki Yonetani

Mikiro Hayashi

Hiroshi Mizoguchi

Naoko Tateishi

Akihiro Senoh

Novel polynucleotides derived from microorganisms belonging to coryneform bacteria and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleotide sequences of the polynucleotide and fragments thereof have been recorded which are readable in a computer, and use of them.

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The present invention relates to a novel glucose-6-phosphate dehydrogenase (hereinafter referred to as 'G6PD') derived from a bacterium belonging to the genus, a DNA encoding the enzyme, a recombinant DNA comprising the DNA, a transformant comprising the recombinant DNA, a transformant comprising the DNA on its chromosome, and a process for producing L-amino acid or G6PD which comprises culturing the transformant. According to the present invention, a modified G6PD and a DNA encoding the G6PD are obtained, and the productivity of L-amino acid by a microorganism can be improved by using the modified G6PD.

Glucose-6-phosphate dehydrogenase

Growing community of inventors

Machida, Japan

Seiko Ando