Teikoku Hormone Mfg. Co., Ltd.

Kao Corporation

Seijiro Honma

Kenyu Shibata

Naoyuki Koizumi

Shigeki Iwashita

Shigehiro Takegawa

Mamoru Mieda

Hiroo Takahashi

Tomoko Kawachi

Kotaro Gotanda

Teruaki Matsui

Shingo Kakuo

Akihiro Izumi

Kikuo Yasuda

Toshimi Seki

Tsutomu Ishimori

Takeshi Masuda

Kaoru Ueda

Koichi Minato

Noriko Haketa

Mitsuteru Numazawa

Kohichi Hasumi

Masako Uno

Fumiko Inoue

The level of a steroid hormone, including estrogen, in the stratum corneum of the skin is assayed by LC-MS analysis of a steroid hormone in the stratum corneum of the skin collected by a tape stripping method. This allows the concentration in the skin of the steroid hormone, including estrogen which has an important effect on the state of the skin, to be easily measured.

Steroid hormone assay method

7-substituted oxa- or azasteroid compound

Oxa- or azasteroid derivatives

A pyridazinone derivative represented by the following general formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, either one of R.sub.2, R.sub.3 and R.sub.4 represents a hydrogen atom and the remaining two of them represent a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and a salt thereof. The compounds are useful as antihypertensive agents.

Antihypertensive pyridazinone aminoisopropanol derivatives

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Yokohama, Japan

Seijiro Honma