Yamanouchi Pharmaceutical Company Ltd.

Merck Patent Gesellschaft MIT Beschrankter Haftung

Seijiro Akamatsu

Yasuo Isomura

Isao Yanagisawa

Yuzo Matsumoto

Toru Yoden

Masafumi Kudou

Tomihisa Kawasaki

Masato Ichihara

Akira Suga

Seiji Kaku

Substituted amidinobenzene derivatives and medicinal compositions thereof

Benzamidine derivatives and pharmaceutical composition containing them

##STR1## A compound represented by general formula (I), a pharmaceutical composition containing same, a process for the production thereof, and an intermediate therefor. In formula (I) R.sup.1 represents lower alkyl which may be substituted by a substituent selected from the group consisting of mercapto, lower alkylthio, arylthio and lower acylthio; R.sup.2, R.sup.3 and R.sup.4 may be the same or different from one another and each represents lower alkyl; X represents oxygen or sulfur; and Y represents a single bond or lower alkylene. The compound (I) has a matrix metalloprotease inhibitory activity and is useful for preventing and treating diseases caused by the progress of connective tissue breakage.

Hydroxamic acid derivative

Growing community of inventors

Ibaraki, Japan

Seijiro Akamatsu