Otsuka Pharmaceutical Factory, Inc.

Seiji Tani

Yasuhiro Mitsumoto

Nobuaki Sumiyoshi

Junji Kaga

Teru Nakai

Masaru Kobayashi

Hideki Kobatake

Seiji Fujita

Yasuhiro Kiuchi

Yui Hayashi

Yu Saruwatari

Miyuki Yamanaka

Hiroshi Kanno

Shigeaki Arita

Shigehito Sekimoto

The present invention provides an infusion preparation that is inhibited from generation of unwanted insoluble matter after mixing of two liquids of the infusion preparation in long-term storage. More specifically, the present invention provides an infusion preparation comprising two chambers separated by a communicably openable partition, a first chamber containing a first-chamber infusion comprising a fat emulsion and further comprising at least one member selected from the group consisting of amino acids that have a buffer action, divalent organic acids, and trivalent organic acids, a second chamber containing a second-chamber infusion comprising an amino acid and at least calcium as an electrolyte, wherein a total concentration of the amino acids that have a buffer action, divalent organic acids, and trivalent organic acids in the first-chamber infusion is 0.15 to 0.5 g/L, and a mixture of the first- and second-chamber infusions has a pH of 6.53 or less as measured 48 hours after the partition is communicably opened.

Transfusion preparation

An object of the present invention is to provide an infusion preparation in which the Maillard reaction between an amino acid and a reducing sugar does not occur during storage and the size of fat particles in the fat emulsion does not increase during storage, and in which various types of vitamins can be incorporated in a stable manner, in spite of the fact that it is a two-chamber infusion preparation. Furthermore, even if only one of the infusions (of the infusion preparation) is administered, the patient is unlikely to develop hyperkalemia, vascular pain, or phlebitis. The present invention provides an infusion preparation containing two chambers separated by a partition that can be communicably opened, wherein a first chamber contains a first-chamber infusion containing a sugar and a fat emulsion, a second chamber contains a second-chamber infusion containing an amino acid and an electrolyte, the first-chamber infusion is substantially free of potassium, and has a relative osmotic pressure of 2.0 to 3.0, the second-chamber infusion has a potassium concentration of 40 mEq/L or less and a relative osmotic pressure of 2.5 to 3.5, and a mixture of the first- and second-chamber infusions has a potassium concentration of 16 mEq/L or more as measured upon communicably opening the partition.

Infusion preparation

There is provided an aseptic combination preparation to be mixed at the time of use, characterized in that the same medicinal ingredients are divided and preserved in two or more chambers. The aseptic combination preparations according to the present invention are a mixing type at the time of their use and are useful as infusions, various dialysis fluids, intraocular perfusion/washing solutions, coronary perfusion solutions, myocardial protective solutions, peritoneal lavage solutions, solutions for organ preservations, etc., which can eliminate adverse effects caused by medical error on a living body.

Aseptic combination preparation

The present invention relates to a polyolefin-made holder for solutions containing vitamin D or derivatives thereof, in which the volume of polyolefin constituting a solution-holding portion of the holder is 30 cm or less per &mgr;mol of the vitamin D or derivatives thereof contained therein; and to a transfusion fluid container comprising the vitamin D solution holder. Use of the holder or container can minimize reduction in vitamin D content.

Vitamin d solution holder and containers for transfusions

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Naruto, Japan

Seiji Tani