Japan Science and Technology Agency

Mitsui Sugar Co., Ltd.

Kyushu University

Sumitomo Chemical Company, Limited

Nissan Chemical Industries Limited

Daicel Chemical Industries, Ltd.

Jnc Corporation

Research Development Corporation of Japan

Institute of Systems, Information Technologies and Nanotechnologies

Other

Panasonic Corporation

Terumo Kabushiki Kaisha

Joled Inc.

Fukuoka Prefectural Government

Nissan Chemical Corporation

Seiji Shinkai

Kazuo Sakurai

Masami Mizu

Takeshi Nagasaki

Kazuya Koumoto

Shuhei Nakatani

Kei Sakanoue

Hidenobu Kakimoto

Atsushi Uno

Osamu Goto

Kozo Tachibana

Osamu Hirata

Takashi Arimura

Tsutomu Matsuda

Munenori Numata

Tony James

Saman Sandanayake

Taro Kimura

Fumiyasu Ono

Masashi Ogawa

Tomohiro Shiraki

Shuichi Haraguchi

Peter C Zhu

Tetsuro Kawanishi

Koichiro Saruhashi

Mark Z Holody

Matthew Albert Romey

Takahiro Matsumoto

Kengo Tabata

Mamoru Nishida

Tatsuhiro Yamamoto

Hirosuke Kawabata

Kirosuke Kawabata

Tomohisa Fujisawa

Masato Ikeda

Masayuki Takeuchi

Shinji Kakimoto

Takeshi Kawazu

Teruaki Hasegawa

Oliver Gronwald

Tetsuro c/o Terumo Kabushiki Kaisha Kawanishi

A novel gelator including a sugar derivative; a gelator including a compound of Formula (1) or Formula (2): wherein Ris a linear or branched alkyl group having a carbon atom number of 9 to 20, a cyclic alkyl group having a carbon atom number of 13 to 20, or a linear or branched alkenyl group having a carbon atom number of 9 to 20, Ris a hydrogen atom, a linear or branched alkyl group having a carbon atom number of 1 to 10, or an aryl group optionally having a substituent, and Rand Rare hydroxy groups.

Sugar derivative gelators

A low-cost cell culture device with low cytotoxicity and improved cell adhesion is described, manufactured by a simplified coating process. At least the portion for cell culture on the surface of the cell culture device is coated with at least one of &#x3b5;-poly-L-lysine, further polymerized derivatives of &#x3b5;-poly-L-lysine and their salts.

Cell culture device and manufacturing method therof

There is provided a novel gelator containing a sugar derivative. A gelator including a compound of Formula (1) or Formula (2): wherein each of Rand Ris independently a linear or branched alkyl group having a carbon atom number of 1 to 20, a cyclic Calkyl group, or a linear or branched alkenyl group having a carbon atom number of 2 to 20, n is 0 or an integer of 1 to 4, Ris a hydrogen atom, a linear or branched alkyl group having a carbon atom number of 1 to 10, or an aryl group optionally having a substituent, and Rand Rare each a hydroxy group.

Sugar-derived gelator

A problem of the present invention is to prevent a base layer beneath the layer to be irradiated with light from deterioration in property and a functional thin film from deterioration in property as the fine patterning of a functional film is performed with light irradiation. Means for solving the problem is a compound obtained by dimerizing with light irradiation a compound (A) containing a group that has photosensitivity and can be photodimerized and a group having lyophilicity and a compound (B) containing a group that has photosensitivity and can be photodimerized and a group having liquid-repellency.

Compound obtained by dimerizing with light irradiation, a compound containing a group having lyophilicity, and a compound containing a group having liquid-repellency

A problem of the present invention is to provide a device having good characteristics and long life, wherein a functional thin film is formed in a desired region by a coating method; a thin film transistor; a method for producing the device; and a method for producing the thin film transistor. This problem can be solved by a device comprising: a substrate, a first electrode formed on the substrate, a functional thin film formed above the first electrode, and a second electrode disposed above the functional thin film, characterized by further comprising, in a region surrounding the region where the functional thin film is formed, a film containing a compound in which a group containing fluorine and a &#x3c0;-conjugated system are bound together by a cycloalkene structure or a cycloalkane structure.

Device, thin film transistor, method for manufacturing the device and method for manufacturing the thin film transistor

A nucleic acid is effectively introduced into a cell while suppressing the cytotoxicity by administering a nucleic acid complex comprising a high molecular weight derivative of &#x3b5;-poly-L-lysine and a nucleic acid to a cell.

Nucleic acid complex and method of introducing nucleic acid into cell using the same

Disclosed is a gene carrier composed of a hydrogen-bonding polymer having a polymer chain with hydrogen-bonding sites formed on the polymer chain, in which the polymer chain has a conformation similar to the conformation of a nucleic acid, and particularly, the polymer chain has helix parameters similar to the helix parameters of a nucleic acid of a helix structure. In a preferred embodiment, the hydrogen-bonding polymer is composed of &#x3b2;-1,3-glucan such as schizophyllan. The carrier can be expected to be applied as a vector and a separator for nucleic acids because it is capable of interacting with a nucleic acid to form a complex with the nucleic acid and thus carrying the nucleic acid.

Gene carrier

Disclosed is a complex which comprises a carbon nanotube and a modified polysaccharide having a backbone chain with the side thereof being introduced with monosaccharide or oligosaccharide residues. The polysaccharide is preferably &#x3b2;-1,3-glucan. The complex is prepared by admixing a solution of the modified polysaccharide dissolved in an aprotic polar solvent or a strong alkali solution with an aqueous dispersion of the carbon nanotube, and incubating the mixture.

Polysaccharide-carbon nanotube complex

Disclosed is a new type of immunostimulating agent including an immunostimulating oligonucleotide complexed with a carrier which is safe and has a high transfection effect. The carrier complexed with the immunostimulating oligonucleotide to form the immunostimulating agent is a polysaccharide having &#x3b2;-1,3-bonds (preferably &#x3b2;-1,3-glucan such as schizophyllan). A preferred example of the immunostimulating oligonucleotide is one containing an unmethylated CpG motif. The polysaccharide for use is preferably modified with nucleic acid-binding functional group and/or cell membrane-affinitive functional group.

Immunostimulating agents

To provide a new technique by which efficient transfection is ensured in delivering a target gene into a cell, disclosed is a nucleic acid construct for nuclear import, which comprises a ternary complex consisting of a nucleic acid substance containing a gene to be delivered into the nucleus of a cell, an importin protein (for example, importin-&#x3b2;) capable of passing through the nuclear pore and involved in the nuclear transport, and a binding substance (for example, polyethyleneimine) bound to both of the nucleic acid substance and the importin protein. Nucleic acid transport from outside of a cell into the cell nucleus can be particularly promoted by administering the nucleic acid construct bound to a cell membrane receptor binding factor and/or a membrane fusing substance, or administering the nucleic acid construct encapsulated in a non-viral vector (for example, Sendai virus envelope) having cell membrane permeability and membrane fusing properties.

Nuclear transport nucleic acid delivery vector

Disclosed are gene carriers utilizing &#x3b2;-1,3-glucan and methods of preparing the same. The &#x3b2;-1,3-glucan has at least one 1,6-glucopyranoside branch and is chemically modified through periodate oxidation and reductive amination so as to impart nucleic acid-binding functional groups (for example, cationic functional groups) to at least some of the 1,6-glucopyranoside branches thereof. Triple helix &#x3b2;-1,3-glucan is dissolved in a polar organic solvent to form single-stranded &#x3b2;-1,3-glucan. By replacing, in the presence of a nucleic acid, the polar organic solvent for the solution containing the chemically modified single-stranded &#x3b2;-1,3-glucan by water, a complex (gene carrier) is formed in which the nucleic acid is bound to double-stranded &#x3b2;-1,3-glucan.

Gene carriers with the use of polysaccharide and process for producing the same

The present invention provides solid-phase saccharide dyes. The dyes are bisboronic acids covalently bonded to a solid substrate. The dyes selectively conjugate with saccharides, particularly glucose, and register a signal. The signal is proportional to the quantity of saccharide. Thus, the dyes of the present invention are useful for measuring and monitoring saccharide levels, particularly in biological fluids such as blood.

Solid-phase saccharide sensing compounds

Disclosed is an aromatic compound expressed by the general formula (I), wherein A represents of a fused aromatic hydrocarbon moiety such as triphenylene, X represents a hydrogen-bonding site such as an atomic group containing an amide linkage, Y represents a chain functional group such as an alkyl group having 3 to 18, preferably 10 to 18 carbon atoms, and n represents an integer ranging from 2 to 10. The aromatic compound forms a molecular assembly in which the aromatic rings mutually overlap and exhibits an excellent charge carrier transfer propertyAX&#x2014;Y). &#x2003;&#x2003;(I)

Aromatic compounds

This invention relates to novel chiral boronic acid compounds which are capable of binding to polyols, particularly to saccharides and are useful in the analysis or separation of diols.

Boronic acid compound having a binaphthyl group

Disclosed is a fluorescent compound of a molecular structure comprising a fluorophore, at least one phenylboronic acid moiety, and at least one amine-providing nitrogen atom where the nitrogen atom is disposed in the vicinity of the phenylboronic acid moiety so as to interact intermolecularly with the boronic acid. The compound emits fluorescence of a high intensity upon binding to saccharide(s), and is therefore suitable for use in the detection of saccharide(s).

Fluorescent compound suitable for use in the detection of saccharides

Growing community of inventors

Fukuoka, Japan

Seiji Shinkai