Taiho Pharmaceutical Company Limited

Seiji Miyahara

Yoshio Ogino

Shoki Hara

Masayoshi Fukuoka

Hiroyuki Ueno

Tatsushi Yokogawa

Hitoshi Miyakoshi

Wakako Yano

Junko Taguchi

Yayoi Takao

The present invention provides a novel sulfonamide compound having a ribonucleotide reductase inhibitory activity or a salt thereof, and a pharmaceutical composition containing the same as an active ingredient. A compound represented by Formula (I) [wherein, Xrepresents an oxygen atom or the like; Xrepresents an oxygen atom; Xrepresents &#x2014;NH&#x2014;; Xrepresents a hydrogen atom or the like; Rrepresents &#x2014;C(R)(R)&#x2014; or the like; Rand Rare the same or different and each represents a hydrogen atom or the like; Rrepresents an optionally substituted C-Caromatic hydrocarbon group or the like; Rrepresents an optionally substituted C-Caromatic hydrocarbon group or the like; Rrepresents a hydrogen atom or the like] or a salt thereof.

Sulfonamide compound or salt thereof

There is provided an agent for potentiating the effects of an anti-tumor agent. An anti-tumor effect potentiator containing, as an active ingredient, a uracil compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein X represents a Calkylene group and one of methylene groups constituting the alkylene group is optionally substituted with an oxygen atom;Rrepresents a hydrogen atom or a Calkyl group; Rrepresents a hydrogen atom or a halogen atom; and Rrepresents a Calkyl group, a Calkenyl group, a Ccycloalkyl group, a (Ccycloalkyl) Calkyl group, a halogeno-Calkyl group or a saturated heterocyclic group.

Anti-tumor effect potentiator

Provided is a uracil compound or a salt thereof, which has potent human dUTPase inhibitory activity and is useful as, for example, an antitumor drug. A uracil compound represented by the general formula (I) or a salt thereof: wherein n represents an integer of 1 to 3; X represents a bond, an oxygen atom, a sulfur atom, or the like; Y represents a linear or branched alkylene group having 1 to 8 carbon atoms, or the like; and Z represents &#x2014;SONRRor &#x2014;NRSO&#x2014;R, wherein Rand Reach represent an alkyl group having 1 to 6 carbon atoms, an aralkyl group which is optionally substituted, or the like; Rrepresents an alkyl group having 1 to 6 carbon atoms, or the like; and Rrepresents an aromatic hydrocarbon group, an unsaturated heterocyclic group, or the like.

Uracil compound or salt thereof having human deoxyuridine triphosphatase inhibitory activity

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Ibaraki, Japan

Seiji Miyahara