Sankyo Company, Limited

Seiji Kumakura

Hiroyuki Koike

Yasuhiro Morisawa

Yasuo Shimoji

Mitsuru Kataoka

Shinsaku Kobayashi

Nobuyoshi Iwata

Yasunobu Sato

Kuniyuki Tomita

Hiromu Takagi

Compounds of formula (I): ##STR1## (wherein Q is oxygen or sulfur, the dotted line is a single or double bond, A is alkylene, and R.sup.1 -R.sup.5 are a variety of atoms or organic groups) have excellent ability to potentiate myocardial contractivity and a variety of other properties, and can be used to treat cardiac disorders.

Pyridazinone derivatives, their preparation and use

Fused ring compounds of formula (I): ##STR1## (where R.sup.1 -R.sup.4, X.sup.1 and X.sup.2 represent hydrogen or various substituents, n and m are 1-3 and 2-7 respectively, the dotted lines are double or single bonds and Y is one oxygen or two hydrogens) have magnificent anti-arrhythmic activity, diuretic activity and the ability to improve brain function.

Fused 5 ring heterocyclic compounds, their preparation, and their

Pyrrolotriazolopyrimidine derivatives having the formula ##STR1## wherein R.sup.1 represents hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R.sup.2 represents an alkyl group having from 1 to 4 carbon atoms, a cycloalkyl group having from 5 to 8 carbon atoms, a phenyl group optionally substituted with one or more halogen atoms or a phenylalkyl group having the formula ##STR2## IN WHICH R.sup.3 represents hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, R.sup.4 represents halogen atom, an alkyl group having from 1 to 4 carbon atoms or an alkoxy group having from 1 to 4 carbon atoms, m represents an integer from 0 to 2 and n represents an integer from 0 to 3, and pharmacologically acceptable salts thereof. The compounds are useful as vasodilating or hypotensive agents and may be prepared by reacting triazolopyrimidine derivatives having the formula ##STR3## wherein X.sup.1 and X.sup.2 may be the same or different and each represents a halogen atom and R.sup.1 has the same meaning as defined above with an amine having the formula

Pyrrolotriazolopyrimidine derivatives and process for the preparation

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Tokyo, Japan

Seiji Kumakura