Dainippon Sumitomo Pharma Co., Ltd.

Seiji Katayama

Naohito Ohashi

Masami Muraoka

Koji Morishita

Kazuki Matsui

Masatoshi Yuri

Takaaki Yamamoto

An optically active form of the quinazolinone derivatives represented by the general formula (1): [wherein Y represents a phenyl group or C2-C7 alkyl group; E represents &#x2014;CH&#x2550; or nitrogen atom; and R represents a C1-C4 alkyl group and so on], or pharmaceutically acceptable salts thereof, has a selective antagonism for the M3 muscarinic receptor and depressant action on the frequency of rhythmic bladder contractions, and it is useful for the treatment of pollakiuria and urinary incontinence.

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Toyonaka, Japan

Seiji Katayama