University System of Maryland

Children's National Medical Center

Seiji Ishii

John Patrick Fisher

Justin Opfermann

Kazue Hashimoto-Torii

Masaaki Torii

Alexander I Son

Peter Cw Kim

Paul D Morton

Judy Liu

Marco Santoro

Porous implantable devices for housing one or more therapeutic agents are disclosed herein. The implantable devices include a porous outer wall defining an interia or void. The interior void houses a carrier material carrying a first therapeutic agent. The implantable devices are made by patterning at least a portion of a polymerizable substrate into a polymerized three-dimensional porous outer wall surrounding an interior void. This can be achieved by two-photon polymerization techniques. A first therapeutic agent is then added to the interior void, which is then sealed. Methods of treating diseases using the implantable devices are disclosed herein. The methods include implanting the implantable device at a target area and locally releasing a therapeutically effective dosage of a first therapeutic agent from the interior void. The implantable devices can also be used in methods of screening potentially therapeutic agents for desired biological responses.

Porous implantable devices

Growing community of inventors

North Bethesda, MD, United States of America

Seiji Ishii