Kyowa Hakko Kirin Co., Limited

Kyowa Hakko Kogyo Co., Ltd.

Kyowa Kirin Co., Ltd.

Seiji Aratake

Kimihisa Ueno

Kazuki Hemmi

Keisuke Yamamoto

Kenji Uchida

Katsuya Kobayashi

Etsuo Ohshima

Michihiko Suzuki

Ichiro Miki

Takeshi Kuboyama

Hitoshi Arai

Masahiro Matsubara

Satoshi Nakanishi

Arata Yanagisawa

Kozo Yao

Koji Suzuki

Masakazu Homma

Koji Yanagawa

Toshimi Kanai

Hiroshi Ishida

Motoki Miyama

Tsutomu Matsumura

Yukihito Tsukumo

Tatsuya Ishimori

Rina Nakamura

Daisuke Harada

Akinori Hamaguchi

Mirai Mizutani

Daisuke Nakashima

Yosuke Yamaura

Ari Kawabe

Takashi Sato

Shinya Fujii

Miho Iwase

Takahiro Kabeya

Maasa Motosawa

The present invention provides a heterocyclic compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof, in which X, R, Y, R, R, and Rare as defined herein. The compound of formula (I) inhibits a C-C chemokine receptor type 10 (CCR10) receptor and is useful as a prophylactic and/or therapeutic agent for skin diseases.

Substituted pyridines and pyridazines as CCR10 receptor inhibitors

The invention provides a pyridone compound represented by the following formula (I) [wherein, Rrepresents cycloalkyl optionally having substituent(s) and the like, Rrepresents a hydrogen atom and the like, Rrepresents hydroxy and the like, and Rrepresents the following formula (R-1) (wherein, Rand Rare the same or different and each represents a hydrogen atom and the like), and the like], or a pharmaceutically acceptable salt thereof, which is useful as a prophylactic and/or therapeutic agent for skin diseases, and the like. 

Pyridone compound

The invention provides a pyrazolopyrimidine derivative of formula (I), wherein, for example, Rrepresents &#x2014;NRR(wherein Rand Rare the same or different and each is a hydrogen atom or aralkyl), Rrepresents formula (Ya) [wherein k and m each represents an integer of 0-2, n represents an integer of 0-4, L represents a single bond, Rrepresents halogen, Rrepresents aryl, X represents &#x2014;CR(wherein Rrepresents a hydrogen atom), and Rrepresents a hydrogen], Rrepresents &#x2014;SOR[wherein Rrepresents lower alkoxy, &#x2014;NRC(&#x2550;O)R(wherein Rrepresents a hydrogen atom, and Rrepresents lower alkyl)], and Rrepresents a hydrogen atom, or a pharmaceutically acceptable salt thereof. The invention also provides a medicament containing the pyrazolopyrimidine derivative, as well as a method of using the pyrazolopyrimidine derivative to prevent and/or treat skin diseases. 

Pyrazolopyrimidine derivative

Provided is an agent for the prevention and/or treatment of a skin disease containing, as an active ingredient, a pyrazolopyrimidine derivative represented by the formula (I) (wherein each symbol is as defined in the specification), or a pharmacologically acceptable salt thereof, and the like.

Agent for prevention and/or treatment of skin diseases

The present invention provides a PPAR &#x3b3; agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein Rrepresents lower alkyl optionally having substituent(s) or the like, Rand Rare the same or different and each represents lower alkyl optionally having substituent(s) or the like, Rand Rare the same or different and each represents a hydrogen atom or the like, Q-Q-Qrepresents CH&#x2550;CH&#x2014;CH&#x2550;CH or the like, Y represents a single bond or the like, Z-Zrepresents C&#x2550;CR(wherein Rrepresents a hydrogen atom or the like), or the like, and A represents &#x2014;COOH or the like), or a pharmaceutically acceptable salt thereof and the like.

Tricyclic compounds

[wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; Rrepresents &#x2014;NRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); Rrepresents the above Formula (II), Formula (IV) or the like; A represents a single bond, &#x2014;C(&#x2550;O)&#x2014;, &#x2014;SO&#x2014;, &#x2014;OC(&#x2550;O)&#x2014; or the like; and Rrepresents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like] Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided. These have anti-inflammatory activities or modulation activities on the functions of TARC and/or MDC and are useful for treating and/or preventing a disease which is related to T cells, such as an allergic disease, an autoimmune disease or transplant rejection.

Bicyclic pyrimidine derivatives

Growing community of inventors

Shizuoka, Japan

Seiji Aratake