Nippon Chemiphar Co., Ltd.

Seiichiro Masui

Shogo Sakuma

Tomio Yamakawa

Takashi Kanda

Tsuyoshi Endo

Toshihiro Takahashi

Shinichi Yoshida

Yutaka Nomura

Kunio Kobayashi

Masatoshi Ushioda

Atsushi Tendo

Nobutaka Mochiduki

Rie Takahashi

Nobutaka Mochizuki

Yoshihisa Nakano

A compound represented by the following general formula (II) or a salt thereof is used as an activator of PPAR&#x3b4;. 

Activating agent for peroxisome proliferator activated receptor &#x3b4;

A compound represented by the following general formula (I):  (wherein Rrepresents phenyl, etc. which can have substituents selected from the group consisting of Calkyl, Calkyl having halogen, halogen, hydroxyl, etc.; Rrepresents Calkyl, etc.; A represents oxygen, sulfur, etc.; X represents Calkylene chain, etc.; Y represents C(&#x2550;O), CH&#x2550;CH, etc.; R, R, and Reach represents hydrogen, Calkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; Rand Reach represents hydrogen, Calkyl, etc.; and Rrepresents hydrogen or Calkyl; provided that at least one of R, R, and Ris not hydrogen) or a salt of the compound; and a PPAR-&#x3b4; activator which contains the compound or salt as the active ingredient.

Activator of peroxisome proliferator-activated receptor &#x3b4;

Activator for peroxisome proliferator-activated receptor &#x3b4;

A compound represented by the formula (I) or a salt of the compound, and a PPAR-&#x3b4; activator which contains the compound or salt as the active ingredient:  (wherein A represents O or S; Brepresents N, etc.; Brepresents O, etc.; each of Xand Xrepresents O, S, a bond, etc.; Y represents Calkylene chain; z represents O or S; Rrepresents aryl, etc. which can have substituents; Rrepresents Calkyl, etc.; Rrepresents Calkyl, Calkenyl, etc.; each of Rand Rrepresents hydrogen, Calkyl, etc.; and Rrepresents hydrogen, etc.; provided that each of Z and Ris attached to the benzene ring, and Xis not attached to the benzene ring).

A compound represented by the following general formula (I): 

Activator of peroxisome proliferator-activated re-ceptor &#x3b4;

A compound represented by the formula (I) or a salt of the compound, and a PPAR-&#x3b4; activator which contains the compound or salt as the active ingredient: 

Activator of peroxisome proliferator-activated receptor delta

A phenylacetic acid derivative represented by the general formula (II) (wherein Rand Reach represents hydrogen, Calkyl, Calkoxy, Calkyl substituted by one to three halogen atoms, an optionally substituted phenyl, naphthyl, pyridyl, thienyl, or furyl group, etc.; Xand Zeach represents &#x2014;C(&#x2550;O)&#x2014;, &#x2014;C(&#x2550;O)NH, &#x2014;NHC(&#x2550;O)&#x2014;, &#x2014;CH&#x2550;CH&#x2014;, a bond, etc.; and Yrepresents a Calkylene chain) or a salt of the derivative; and a PPAR&#x3b4; activator which contains the derivative or salt as the active ingredient 

Activator for peroxisome proliferator-activated receptor

Compounds of the general formula (I) or salts thereof and activators of PPAR&dgr; (peroxisome proliferator activated receptor &dgr;) containing the compounds or the salts as the active ingredient: wherein R and R each are hydrogen, C alkyl, an aryl or heterocyclic group which may be substituted, or the like; A is oxygen, sulfur, or the like; X and X are each a free valency, oxygen, S(O) (wherein p is an integer of 0 to 2), C(&boxH;O), C(&boxH;O)NH, NHC(&boxH;O), CH&boxH;CH, or the like; Y is optionally substituted C alkylene; Z is oxygen or sulfur; R and R are each optionally substituted C alkyl; and R is hydrogen or C alkyl, with the proviso that when X is a free valency, X is not O or S(O) , while when X is C(&boxH;O)NH, X is not a free valency.

Growing community of inventors

Saitama, Japan

Seiichiro Masui