Snow Brand Milk Products Co., Ltd.

Other

Show Brand Products Co., Ltd.

Fujino Patent Attorney

Seiichiro Aoe

Yukihiro Takada

Junichi Yamamura

Ken Kato

Masaaki Goto

Atsushi Serizawa

Mototake Murakami

Hiroaki Matsuyama

Hidetoshi Ishikawa

Tomoe Yoshioka

Kiyoshi Tatsumi

Toshiaki Uchida

Hiroaki Konishi

Masatoshi Yahiro

Seiji Kurosawa

Masami Kawanari

Sachiko Yahagi

Yasuhiro Toba

Taishi Oda

Masanori Nakaoka

Toshimitsu Yoshioka

A highly safe bone resorption suppressing agents, which can be used as medicines or admixed to food products or feeds, is produced. Milk-derived basic cystatins and/or milk-derived basic cystatin decomposition products prepared from milk are made into bone resorption suppressing agents, or admixed to drinks, food products and feeds.

Bone resorption suppressing agent

The present invention is to provide a novel medicine, drink, food or feed having an action of strengthening bone. More specifically, the present invention is to provide a medicine, drink, food or feed combined with collagen, fraction containing collagen or degradation product thereof. Fraction containing collagen was prepared by mincing skin corium layer into pieces, defatting it and lyophylization or by pulverizing bone, decalcifying it and lyophylization. Oral administration of these can stimulate proliferation of osteoblast, inhibit bone resorption and strengthen bone. They can be useful for improvement of osteoporosis, bone fracture, bone pain, etc.

Medicine drink food and feed having an action of strengthening bone

The present invention provides a basic protein and a basic peptide composition which can be administered orally and has the ability to stimulate osteoblast proliferation, strengthen bone and inhibit bone resorption. Said basic protein has the following properties: (1) a molecular weight distribution of is 2,000-24,000; (2) an isoelectric point distribution of is 7.5-11; and (3) it is comprised of more than 10% of basic amino acids. Said composition can be obtained by the following steps: After milk, or raw material derived from milk, is loaded onto a cation exchange resin column, a fraction is obtained by eluting with an eluent of 0.1-1.0M salt concentration, precipitate removed by (i) heating to over 75.degree. C., (ii) by adding alcohol so that the final concentration thereof is 10-50% or (iii) by adding salts so that the final concentration thereof will be more than 0.2M; and the supernatant thereof containing the basic protein fraction recovered.

Basic protein composition, basic peptide composition and application

A bone reinforcing agent comprising a basic protein fraction or a basic peptide fraction derived from milk as an effective component is described. The basic protein fraction is obtained by passing milk or a raw material derived from milk over a cation exchange resin and eluting the adhered fraction. The basic peptide fraction is obtained by hydrolyzing the basic protein fraction with a protease. The basic protein fraction and basic peptide fraction of the present invention promote the growth of osteoclasts and suppress the resorption of osteoclasts, and thereby strengthening bone when administered orally. The invention is useful for treating or preventing bone diseases such as osteoporosis.

Bone reinforcing agent and foods and drinks product containing the same

The present invention will provide an agent promoting bone formation and inhibiting bone resorption comprising kininogen and degradation product of kininogen as an effective ingredient. Fragment 1.multidot.2 is a preferable degradation product of kininogen. Further, the present invention will provide a drink, food, medicine and feed combined with kininogen and degradation product of kininogen.

Kininogen agent promoting bone formation and inhibiting bone resorption

A method for promoting osteoblast proliferation or inhibiting bone resorption comprising administering to a subject in need thereof, a composition comprising High Mobility Group Protein (HMG-1) is disclosed.

Promoting bone formation and inhibiting bone resorption with high

The present invention provides a well-digestible and well-absorbable edible oil and fat composition containing 20% by weight or more 2-palmitoyl-1,3-dioleylglycerol. Also a process for production of the above edible oil and fat composition which comprises fractionating the edible oil and fat composition to increase the content of 2-palmitoyl-1,3-dioleylglycerol to 20% by weight or more is disclosed. The edible oil and fat composition of the present invention is useful as a fat material used in diets for infants or for the sick.

Method of fractionating an edible oil containing

Oil and fat composition having decreased digestive and absorptive

The present invention provides a process of producing a water-soluble hemicellulose comprising a starch removing stage, an extraction stage and a neutralization and desalting stage and the use of the obtained water-soluble hemicellulose as a health food.

Water-soluble hemicellulose

Growing community of inventors

Sayama, Japan

Seiichiro Aoe