Freund Industrial Co., Ltd.

Kirin Brewery Company, Limited

Kirin Beer Kabushiki Kaisha

Japan Greenwave Ltd.

Freund Industry Company, Limited

Seiichi Umeda

Shimesu Motoyama

Hiroaki Ogishima

Hirotsune Yasumi

Takuichi Tsujino

Sashiro Motegi

Yukihiro Saito

Shigeru Ohno

Satoshi Sato

Kenji Sugibayashi

Yuji Sakamoto

Yasunori Morimoto

Emiko Sudo

Akira Akazawa

Shimesu Motoyama, Deceased

Satashi Sato

Naomi Yoshida

Emiko Suto

Yuko Takasaka

An aqueous solution containing a high concentration of ginkgo leaf extract having good preservability is prepared. The aqueous solution containing ginkgo leaf extract comprises at least 1 weight % of a hydrous organic solvent extract obtained from ginkgo leaf, and further disaccharide alcohols and/or trisaccharide alcohols, and/or organic compounds having a basic nitrogen atom in the molecule and a solubility in water at normal temperature of at least 10 g/100 ml.

Aqueous solution containing ginkgo leaf extract

Percutaneous or trans-mucosal absorption enhancer comprising of a terpeneketone and preparation containing thereof. Preferably, the preparation contains a percutaneous or trans-mucosal absorption enhancer in an amount of 0.01-20 weight % of the preparation. In preparing the preparation, a terpeneketone is dissolved and emulsified in a water soluble organic solvent which is medically allowable.

Percutaneous or trans-mucosal absorption enhancers, preparations

A composition containing an extract obtained by a water-containing organic solvent, comprising: (a) an extract containing active ingredients including flavone glycoside or biflavone almost insoluble in water, said extract being obtained for ginkgo plant tissues by extraction with a water-containing organic solvent, and at least one of (b) a water-soluble high-molecular substance and (c) a fatty acid ester of polyglycerol. This composition can be formulated into preparations not containing ethanol, i.e. solid preparations including tablets, granules, and powder preparations, or non-alcoholic liquid preparations such as drinkable preparations and syrups, in such a way that the extract contained is well absorbed through the digestive tract.

Process for preparing a watersoluble composition containing ginkgo leaf

A sustained-release granule of sugar comprising a core comprising primarily one or more of a monosaccharide, a disaccharide and a trisaccharide and an outer film comprising 10-90% by weight of an ethylene-vinyl acetate copolymer and 90-10% by weight of a wax. This sustained-release granule of sugar may be prepared by coating a core comprising primarily one or more of a monosaccharide, a disaccharide and a trisaccharide with a coating material comprising 10-90% by weight of an ethylene-vinyl acetate copolymer and 90-10% by weight of a wax by spraying a solution of the coating material onto the core while tumbling or fluidizing the core. The sustained-release granule of sugar can be applied in an artificial seed comprising an active plant tissue and the sustained-release granule of sugar which are encapsulated in a gel matrix.

Artificial seed comprising a sustained-release sugar granule

Disclosed is a preservative composition for foodstuffs and the like, which is comprised of (i) a metal powder or a granulated product thereof, (ii) an oxidation accelerator for the metal, (iii) polyallylamine, and (iv) an optional ethanol vapor-generating member. The polyallylamine is preferably deodorized by loading a solution of polyallylamine or a salt thereof on a carrier, and heating and drying the polyallylamine-loaded carrier.

Preservative composition

A delivery unit of plant tissue of the present invention comprises a vessel in which meristematic tissue having the ability to grow into an entire plant body through differentiation is received. The body of the vessel is made of water-soluble substance and the interior thereof is covered with a water-insoluble substance. Hydrogel is charged in the vessel and the meristematic tissue is held by the hydrogel in a state in which its root or rooting portion is embedded therein or it is placed on the hydrogel. The vessel has a structure of a closed type with a cap or an open type. When the delivery unit of plant tissue is seeded in a medium, the water-soluble substance of the vessel body is dissolved by water contained in the medium and the bud and root grown out of the meristematic tissue breaks the thin film made of a water-insoluble substance which is provided in the interior of the vessel so as to further grow out.

Delivery unit of plant tissue

A method in which a plant meristematic tissues which retain aqueous liquid on their surfaces are mixed with fine powder, thereby forming powder-coated bodies to which fine powder is adhered at the periphery thereof, so that meristematic tissues are separated from each other. A quantity of water or a liquid mainly consisting of water large enough to make fine powder adhere to the surfaces of the meristematic tissues which can grow into entire plant bodies directly or after they have passed through differentiation and organogenesis. The meristematic tissues are mixed with the fine powder which does not indicate adhesiveness at least during the mixing process. This mixing process is effected in such a manner that the powder is adhered to the tissues by gently shaking or agitating them without applying excessive shearing stress to the meristematic tissues.

Powder coating method

An oral pharmaceutical composition which comprises a polyglycerol ester of an unsaturated fatty acid and a drug which is very slightly soluble in water.

Pharmaceutical composition of cyclandelate having a high degree of

Disclosed is a process for the preparation of an activated pharmaceutical composition containing a solid drug that is scarcely soluble in water, the pharmaceutical composition being characterized in that, when it is administered orally, the drug is readily absorbed to attain its high blood concentration quickly. This process is carried out by providing a solid drug that is scarcely soluble in water, dispersing the drug in water in the presence of a water-soluble high-molecular substance to form a disperse system containing the drug in the form of finely divided particles substantially not greater than 10.mu. in diameter, and then removing the water from the disperse system.

Growing community of inventors

Tokyo, Japan

Seiichi Umeda