Ajinomoto Co., Ltd.

Seiichi Nishi

Daisuke Takahashi

Satoji Takahashi

Kunisuke Izawa

Tetsuo Suami

Masanobu Yatagai

Kazuo Ohishi

Toshihiro Matsuzawa

Tsuyoshi Shiio

Tohru Nishiwaki

There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture being obtained by reacting trans-4-isopropylcyclohexylcarbonyl chloride with D-phenylalanine in a mixed solvent of ketone solvent and water in the presence of an alkali; and then adjusting the temperature of the mixture to 58&#xb0; C. to 72&#xb0; C. and the concentration of ketone solvent to more than 8 wt % and less than 22 wt % to conduct precipitation of nateglinide crystals. This producing method is the industrially beneficial methods for crystallization of nateglinide.

Methods for producing nateglinide crystals

A pure (-)-9-[1'S, 2'R-bis(hydroxymethyl)cyclopropan-1'-yl]methylguanine is prepared by:

Method for purifying nucleic acid derivatives

Platinum complexes of cis-diaminocyclohexanol or cis-diaminocyclohexane, with the exclusion of platinum complexes of 2-deoxystreptamine, having high anti-tumor activity, low toxicity, water-solubility and exhibiting no cross-resistance to cis-platin.

Platinum complexes and uses therewith

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Yokkaichi, Japan

Seiichi Nishi