Teijin Limited

Teijin Pharma Limited

Seiichi Ishizuka

Kazuya Takenouchi

Kenji Manabe

Qingzhi Gao

Yasuhiro Takano

Ryo Sogawa

Junji Kubo

Hiroshi Saito

Atsuo Hazato

Atsushi Imaizumi

Kiyoshi Bannai

Hiroko Tanaka

Nozomi Saito

Minoru Furuya

Masayasu Tabe

Hiroaki Takayama

Kazuhisa Okada

Noriyoshi Kurihara

Daishiro Miura

Tatuyuki Naruchi

Yasuji Sakuma

Toshie Fujishima

Yasuhiro Oue

Hiroaki Mitsuhashi

G David Roodman

Norio Ohnuma

Manabu Chokki

Tadashi Kishimoto

Sakamuri V Reddy

Atsushi Kittaka

Miyuki Anzai

Miyuki Anzal

A compound represented by the following Formula (1) that is effective for the treatment of Paget's disease of bone or hypercalcemia or a medically acceptable solvate thereof; [wherein Rrefers to hydrogen atom, C-Calkyl group optionally substituted with hydrogen group or C-Calkoxy group optionally substituted with hydroxyl group, Rand Rrefer to hydrogen atom, C-Calkyl group optionally substituted with hydroxyl group, C-Caryl group optionally substituted with hydroxyl group or C-Caralkyl group optionally substituted with a hydroxyl group, or are combined to represent ethylene group. However, a compound in which Ris a hydrogen atom or a methyl group and Rand Rare hydrogen atoms is excluded].

[object Object]

To obtain a treating agent for Paget's disease of bone, there is provided a method of inhibiting expression of general transcription factor of steroid hormone receptor.

Treating agent for Paget's disease of bone

Compounds expressed by the following general formula (1),[wherein, Rand Rare each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1), (1-2), (1-3), (1-4) and (1-5)].The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.

Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same

Compounds expressed by the following general formula (1),[wherein, Rand Rare each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1) to (1-5)].The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.

Vitamin D, derivatives and remedies for inflammatory respiratory diseases containing the same

Vitamin D.sub.3 derivative and treating agent for inflammatory

The present invention relates to a method of controlling the concentration of calcium in the serum of warm-blooded animals characterized by the administration of a pharmaceutically effective amount of 25-hydroxyvitamin D.sub.3 -26,23-lactones expressed by the following formula (I) ##STR1## wherein R indicates a hydrogen atom or a hydroxyl group and X indicates --O-- or --O--O--, to warm-blooded animals, and a pharmaceutical composition to be used for controlling the concentration of calcium in the serum of warm-blooded animals which comprises 25-hydroxyvitamin D.sub.3 -26,23-lactones expressed by the above-mentioned formula (I) and a pharmaceutically acceptable carrier. 25-hydroxyvitamin D.sub.3 -26,23-lactones are desirably used especially for the treatment or prevention of the diseases resulting from the high calcium levels in the serum.

Methods of controlling the concentration of calcium in the serum of

Novel 1.alpha.-hydroxy-24-dehydrovitamin D.sub.3 and its hydroxyl-protected derivatives; novel 1.alpha.-hydroxy-24-dehydroprevitamin D.sub.3 and its hydroxyl-protected derivatives; and novel 1.alpha.,3.beta.-dihydroxycholesta-5,7,24-triene or its hydroxyl-protected derivatives which are key intermediates for preparing the aforesaid compounds. Novel processes for preparing these compounds are also provided. 1.alpha.-Hydroxy-24-dehydrovitamin D.sub.3 has a pharmacological action of controlling the calcium metabolism of warm-blooded animals, and is useful as a prophylactic or therapeutic pharmaceutical for vitamin D deficient disease and related diseases.

1.alpha.-Hydroxy-24-dehydrovitamin .sub.3 pharmaceutical compositions

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Tokyo, Japan

Seiichi Ishizuka