Sankyo Company, Limited

Seigo Ueda

Takashi Shiokari

Masayuki Iwata

Atsushi Hattori

Yuichiro Yabe

Yoshihiko Baba

Kunio Hashi

Yukinori Kawahara

Akira Kusai

Sadamasa Minato

In a freeze-drying method for producing a dried pharmaceutical compound or preparation, a first liquid is frozen, a second liquid is added to the frozen first liquid and is frozen thereon, and the frozen first and second liquids are freeze-dried together, in which at least one of said first and second liquids contains said pharmaceutical compound of preparation dissolved or suspended therein. The other liquid or liquids may be pure solvent (generally water) or may contain one or more other substances.

Method of preparing a freeze-dried formulation containing a drug

Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially.

Composition containing a penem or carbapenem antibiotic and the use of

Improvement in determination of an enzyme activity in a substance having an enzymatic activity which comprises employing an aromatic primary amine derivative as a substrate and an iron complex treated with a peroxide as a color reagent.

Method for the determination of enzyme activities

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Shinagawa, Japan

Seigo Ueda