Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Bio Co., Ltd.

Juridical Foundation, Japanese Foundation for Cancer Research

Other

Seiga Itoh

Moriyuki Sato

Tetsuro Kuga

Kazuo Yamaguchi

Hiromasa Miyaji

Motoo Yamasaki

Makoto Morimoto

Susumu Sekine

Tatsunari Nishi

Yoshiharu Yokoo

Masami Okabe

Yoshinori Komatsu

Hajime Yoshida

Akiko Saito

Tamio Mizukami

Shinkichi Honda

Tadatsugu Taniguchi

Haruo Sugano

Tetsuo Oka

Akira Furuya

Akio Ozaki

Ryoichi Katsumata

Kunikatsu Shirahata

Katsutoshi Sasaki

Tadashi Matsumoto

Toru Mizukami

Tetsuya Hirano

Mitsuaki Yoshida

Hiroshi Kawauchi

Shigeyoshi Yasumura

Yasutoshi Takeichi

Motoko Kageyama

Morimasa Yagisawa

Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.

G-CSF conjugate

A novel motilin analog peptide containing leucine instead of the usual 13th amino acid methionine, as in the naturally occurring motilin, is produced by gene recombination techniques in which several or identical genes, each coding for the novel peptide, are joined in series into a vector. The resultant recombinant DNA is introduced into Escherichia coli and the resultant transformant is cultivated. The resulting polymeric peptide can be cleaved to give the desired peptide.

DNA coding for (Leu.sup.13) motilin

Method of producing a polypeptide having human granulocyte colony

Polypeptide derivatives of human granulocyte colony stimulating factor

DNAs coding for �LCU.sup.13 ! motilin

Method for producing �Leu.sup.13 !motilin

DNA encoding human granulocyte colony stimulating factor plasmids and

[Leu13]motilin, DNAs coding for same and methods for producing same

Disclosed is a process for expressing a gene and producing a metabolic product formed by the gene by culturing a transformant microorganism carrying a recombinant DNA constructed of a DNA fragment having at least one gene to be expressed and a vector DNA, at least one of which is foreign to the host microorganism.

Amino acid synthesis in corynebacteria using E. coli genes

A polypeptide or glycosylated polypeptide with at least one new carbohydrate chain produced by means of recombinant DNA technique, which has protease resistance and thermal stability and is expected to have longer lifetime in blood than those of a naturally-occurring form.

Modified granulocyte-colony stimulating factor polypeptide with added

The present invention provides a hybrid antigen polypeptide having both antigenicity of the ATLA encoded by gag gene and that of the ATLA encoded by env gene. The hybrid antigen can be produced in a large amount and it is applicable to serum diagnosis of patients infected with antigen polypeptides such as ATLV.

Method of producing an adult T cell leukemia virus fused antigen

Fused antigen polypeptide

Growing community of inventors

Kanagawa, Japan

Seiga Itoh