Spring Bank Pharmaceuticals, Inc.

F-Star Therapeutics, Inc.

Cambridge Neuroscience, Inc.

Invox Pharma Limited

Scion Pharmaceuticals, Inc.

Sperovie Biosciences, Inc.

Spring Bank

Seetharamaiyer Padmanabhan

Radhakrishnan P Iyer

Rayomand H Gimi

Shenghua Zhou

Sreerupa Challa

Anjaneyulu Sheri

Geeta Meher

Dillon Cleary

Graham J Durant

James B Fischer

Michael Perlman

Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.

Compounds, compositions, and methods for the treatment of disease

Compounds,compositions, and methods for the treatment of disease

Compounds,Compositions, and methods for the treatment of disease

The present invention provides compositions methods for treating susceptible viral infections, especially hepatitis C viral (HCV) infections as well as co infections of HCV with other viruses such as HBV and/or HIV. In one embodiment, the present invention provides compositions having the formula (I) and their use in treating viral infections: 

Compositions and methods for treating viral infections

The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Nucleotide and oligonucleotide prodrugs

The present invention describes extremely rapid and efficient methods for the attachment of chemical moieties to matrices by the use of microwave technology. The methods of the invention can be applied in a variety of ways for the preparation of different types of matrices for a variety of applications including but not limited to the functionalization of various solid supports, and matrices in the form of powder, beads, sheets, and other suitable surfaces for use in applications including but not limited to oligonucleotide synthesis, peptide synthesis, environmental clean up (removal of toxic materials), immunoassays, affinity chromatography, combinatorial chemistry, microarrays, proteomics and medical diagnostics.

Methods and processes for attaching compounds to matrices

The present invention relates to pharmaceutically acceptable compounds, including acylguanidine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.

Pharmaceutically active compounds and methods of use

This invention relates to racemic and optically active N-(2-chloro-5-methylthiophenyl)-N&prime;-(3-methylsulfinylphenyl)-N&prime;-methylguanidine, N-(2-chloro-5-methylsulfinylphenyl)-1-(7-trifluoromethyl- 1,2,3,4-tetrahydroquinolinyl)carboximidamide, and N-(3-methylsulfinylphenyl)-N-methyl-N&prime;-(2-chloro-5-methoxyphenyl)guanidine and pharmaceutically acceptable salts thereof, and pharmaceutical compositions and therapeutic methods of treatment that comprise such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.

Pharmaceutically active compound and methods of use

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Lexington, MA, United States of America

Seetharamaiyer Padmanabhan