National University of Singapore

Nkarta, Inc.

Agency for Science, Technology and Research (a*star)

Agency for Science and Research

See Voon Seow

Dario Campana

Alexandra Leida Liana Lazetic

James Barnaby Trager

Chao Guo

Luxuan Guo Buren

Prasanna Ratnakar Kolatkar

Jun Hao Leong

Noriko Shimasaki

Shyam Sashikant Masrani

Kaw Yan Chua

Several embodiments disclosed herein relate to the compositions comprising engineered Natural Killer (NK) cells that express a chimeric receptor, the chimeric receptor imparting to the NK cells an enhanced ability to target specific cells, such as cancerous cells or those affected by an infectious disease. Several embodiments relate to NK cells that target cells expressing natural ligands of NKG2D, where the NK cells comprise transmembrane and/or signaling domains that lead to cytotoxic and/or cytolytic effects when the NK cells bind a target cell. Uses of NK cell compositions to treat diseases are also provided for in several embodiments.

Immune cells comprising truncated NKG2D chimeric receptors

Current invention relates to a polynucleotide encoding activating chimeric receptors comprising engineered Natural Killer Group 2 member C (NKG2C) having enhanced affinity for HLA class I histocompatibility antigen alpha chain E (HLA-E)/peptide complex or an extracellular receptor domain of NKG2A coupled to an effector domain. It also relates to NK cells expressing such constructs and the use of these NK cells to induce cytotoxicity. It further exemplifies that the NK cells expressing polynucleotide encoding NKG2C (SIIS)/CD94/DAP12 or NKG2C/CD94/4-1 BB/CD3z showed enhanced NK cytotoxicity against cancer cells.

Activating chimeric receptors and uses thereof in natural killer cell immunotherapy

Truncated NKG2D chimeric receptors and uses thereof in natural killer cell immunotherapy

We describe an Fve polypeptide being a fragment, homologue, variant or derivative of Fve protein, which comprises at least one biological activity of Fve protein. uses of such a polypeptide, etc, and nucleic acids encoding these, in the treatment and prevention of allergy and cancer are also disclosed.

Molecule

We describe an Fve polypeptide being a fragment, homologue, variant or derivative of Fve protein, which comprises at least one biological activity of Fve protein. Uses of such a polypeptide, etc, and nucleic acids encoding these, in the treatment and prevention of allergy and cancer are also disclosed.

Growing community of inventors

Singapore, Singapore

See Voon Seow