Rhodia Operations

Solvay (China) Co., Ltd.

Rhodia Chimie

Rhodia (China) Co. Ltd.

Sébastien Righini

Jean-Pierre Simonato

Floryan De Campo

Tania Ireland

Claude D Mercier

Claude Mercier

Didier Bonnet

Romain Petroff Saint-Arroma

A process for preparing a 5-halophenol, ortho-substituted by an electron-donating group, is described. Also described, is a process for preparing a sulphonic ester of an ortho-substituted phenol, which is the synthesis intermediate for the ortho-substituted 5-halophenol. The process for preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester can include reacting a phenol ortho-substituted by an electron-donating group with a sulphonylating agent in the presence of a Lewis acid. The process for preparing a 5-halophenol ortho-substituted by an electron-donating group can include a first step of preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester, as described above; a second step of halogenating the protected phenol intermediate obtained in the preceding step, in the position para to the electron-donating group; and a third step of deprotecting the sulphonic ester function to hydroxyl.

Process for preparing an ortho-substituted 5-halophenol and a synthesis intermediate thereof

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Lyons, France

Sébastien Righini