Galderma Research & Development

Sebastien Daver

Thibaud Biadatti

Sandrine Talano

Laurence Dumais

Catherine Soulet

Jean-Guy Boiteau

Eric Terranova

Jean-Claude Pascal

Nicolas Rodeville

Christine Marty

The present invention relates to a novel process for preparing enantiomerically pure compounds of N-(pyrid-4-yl)-2-hydroxyalkylamide type corresponding to the general formula (C) below:  and also to processes for preparing the reaction intermediates used in this synthesis, said intermediates having the general formulae (A) and (B) below: 

Method for synthesizing enantiomerically pure N-(pyridin-4-yl)-2-hydroxy-alkylamide derivatives

Novel ligand compounds having the general formula (I): and pharmaceutical/cosmetic compositions comprised thereof are useful in human and veterinary medicine or, alternatively, in cosmetics.

Ligands that modulate RAR receptors

Ligands that modulate RAR receptors and pharmaceutical/cosmetic compositions comprised thereof

3-[5'-(3,4-bis(hydroxymethyl)benzyloxy)-2&#x2032;-ethyl-2-propylbiphenyl-4-yl]pentan-3-ol is prepared from the novel intermediate, 6-ethyl-4&#x2032;-(1-ethyl-1-hydroxypropyl)-2&#x2032;-propylbiphenyl-3-ol.

Preparation of 3-[5'-(3,4-bis(hydroxymethyl)benzyloxy)-2&#x2032;-ethyl-2-propylbiphenyl-4-yl]pentan-3-ol

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Antibes, France

Sebastien Daver