Emd Millipore Corporation

Millipore Corporation

Sebastien Cirou

Jean-Louis Weissenbach

Rene Reinbigler

Virginie Buisson

Cecile Delbos

Frans Mels

Jean-Luc Beulay

Marc Hlavacek

Christine Abouayad El Idrissi

Jim E Kelly

Ronald Tuccelli

Jean Luc Beulay

Jean Louis Weissenbach

Laurent Jourdainne

The invention concerns an installation for treating biological liquid by viral inactivation, comprising a main supply valve () for suppling biological liquid to treat, a first line () downstream of said valve and provided with a first main tank (), a second line () downstream of said valve and provided with a second main tank (), said second line being in parallel with said first line, and a third main tank () disposed at an outlet both from said first line and said second line and configured to be successively supplied by said first main tank and by said second main tank; said installation being configured such that in each of said first, second and third main treatment tanks, a determined volume of acid and a determined volume of base are introduced at least so as to adjust a pH of said biological liquid and to regulate a rate of drainage flow of said third main treatment tank so as to provide a continuous rate of flow of treated biological liquid at an outlet from said installation.

Installation for treating biological liquid

The invention concerns an installation for treatment of biological liquid by chromatography, extending in a longitudinal direction and comprising a supply valve (), a supply pump () downstream of the valve, instrument members downstream of the pump including distribution valves (---) and devices (---) for measuring physico-chemical parameters of the liquid, chromatography columns (-) downstream of the instrument members and pipes connecting the valve, the pump, the instrument members and the columns so as to form at least one supply line for biological liquid to treat of a treatment circuit of said installation, the chromatography columns being disposed relative to each other in a direction of extension generally transverse to said generally longitudinal direction of extension of the installation.

The invention concerns an installation for treating biological liquid by chromatography, extending in a longitudinal direction and comprising a supply valve (), a supply pump () downstream of the valve, instrument members downstream of the pump among which are at least one distribution valve (---) and at least one device (---) for measuring a physico-chemical parameter of the liquid, at least one chromatography column (-) downstream of the instrument members and of the pipes connecting the valve, the pump, the instrument members and the column, instrument members being associated with the chromatography column and each mounted on at least one dedicated control and actuation platform (-), which extends in a vertical direction relative to the generally longitudinal direction of extension of said installation, and which are disposed substantially above each other on said dedicated control and actuation platform.

The invention concerns a device comprising a base () and a door (), said device having a closed door position in which a circuit () of the device comprises a bag comprising two flexible films and connectors of the conveying network, and a press () comprising a first shell () disposed on a front face () of said base () and a second shell () disposed in said door (); and a hinge system hinging said door () relative to said base (), and disposed only on one side of said door () so as to form lateral clearances between said door () and said base () over the rest of a perimeter of said door ().

Device for a biological liquid treatment installation

The invention concerns a circuit comprising a bag () comprising two flexible films () and a press () comprising a first () and a second () shell clamping the bag to form pipes having a passage and edges (41); the first shell comprising a valve () which comprises a movable member () and a pad (), which pad has a resting configuration in which a second face () of the pad is concave and locally delimits a channel () and a pinching configuration in which the second face () is convex; said movable member and said pad being configured so that, when said valve is in closed position and said pad in pinching configuration, said passage is pinched by said movable member against said second shell channel and said edges () are pinched flat by said movable member against said second shell ().

Circuit for biological liquid comprising a pinch valve

The invention concerns a device comprising a base () and a door (), said device having a closed door position in which a circuit () of the device comprises a bag comprising two flexible films and connectors of the conveying network, and a press () comprising a first she () disposed on a front face () of said base () and a second shed () disposed in said door (); and a hinge system hinging said door () relative to said base (), and disposed only on one side of said door () so as to form lateral clearances between said door () and said base () over the rest of a perimeter of said door ().

The invention concerns a device comprising:

The invention concerns a filtration device comprising a manifold providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.

Device for filtration with a set of least one filter cassette

The invention concerns a filtration device comprising a providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.

The invention concerns a bag comprising a first conduit (C) which extends longitudinally between a flow pump connector (C) emerging on a first side () and a tangential filter connector (M) emerging on a second side (); a second conduit (B) which extends longitudinally from a first side of said conduit (C) between a supply container connector (B) emerging on said first side (), and another tangential flow connector (N) emerging on said second side (); a third conduit (H) which extends from a second side of said conduit (C), starting at a collecting container connector (J), until it enters said first conduit (C); and a fourth conduit (A) which extends from the first side of said conduit (C), starting at a transfer pump connector (A), until it enters said second conduit (B).

Bag for a circuit of a biological liquid treatment installation

The invention concerns a device comprising a circuit comprising a bag () comprising two flexible films (), a press () comprising a first shell () disposed upright on a front face of a base of the device and a second shell () mounted on said first shell, which shells clamp said bag to form conduits (); said press is provided with a system () for jamming at the location of a treatment zone () of the bag, which comprises a jamming member () provided with at least one jamming nipple () and a complementary jamming member () provided with a jamming channel () configured to receive said nipple; said jamming member () and complementary jamming member () and said bag () being configured in order for the latter to have a portion () in said treatment zone in which said films are jammed between said nipple and said channel.

The invention concerns a device comprising a base; a circuit comprising a bag comprising two flexible films and conveying network connectors, and a press () comprising a first shell () disposed upright on a front face () of said base () and a second shell () mounted on said first shell (), said first shell () and second shell () clamping said bag to form conduits;

The invention concerns a circuit comprising a bag () comprising two flexible films () and routing network connectors, and a press () comprising a first shell () and a second shell () clamping the bag to form pipes () between the films, the first shell comprising a pinch valve () which comprises an actuator () comprising a movable member () and in register with the moveable member an elastically compressible pad () which, when the valve is in an open position, has a resting configuration in which a second face () of the pad is concave and locally delimits a shaping channel (), and, when the valve is in a closed position, has a pinching configuration in which the second face () is convex, with the pipe and the pad sandwiched between a shaping channel () and the moveable member.

Circuit for biological liquid

The invention concerns a bag comprising a first conduit (J), a second conduit (K), the first section (J) of the first conduit (J) and the first section (K) of the second conduit (K) being opposite; a third conduit (L) linking said first respective ends (JK) of said first respective sections (JK); a fourth conduit (M) linking said second respective ends (JK) of said first respective sections (JK); a fifth conduit (N) linking both said second end (J) of said first section (J) and said first end (M) of said fourth conduit (M), and said fifth conduit (N) linking both said first end (K) and said second end (L) of said third conduit (L); said first conduit (J) and said second conduit (K) each being connected to a chromatography column connector (M).

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Schiltigheim, France

Sebastien Cirou