Ascendis Pharma A/s

Deere & Company

Te Connectivity Germany Gmbh

Ascendis Pharma Ophthalmology Division A/s

Audi Ag

Ascendis Pharma Oncology Division A/s

Sebastian Stark

Harald Rau

Juha Punnonen

Nicola Bisek

Samuel Weisbrod

Frederic Ballaire

Romy Reimann

Kennett Sprogøe

Torben Lessmann

Thomas Knappe

Tobias Voigt

Burkhardt Laufer

Patrick Bechtold

Andreas Wehle

David B Rosen

Kennett SprogØe

Luis Zuniga

Yang Yang-malten

Lars Holten-andersen

The present invention relates to hydrogel prodrug compositions comprising cross-linked hyaluronic acid (HA), or a derivative or a salt thereof, wherein the cross-linker system comprises a biodegradable spacer, wherein the cross-linked HA comprises a conjugated drug-linker, and wherein the linker is capable of releasing the drug under physiological conditions. The present invention further relates to methods for preparing the hydrogel prodrug compositions. The present invention further relates to methods for treating an ocular condition using the hydrogel compositions.

Hydrogel cross-linked hyaluronic acid prodrug compositions and methods

A method for unloading a payload at a loading station includes selecting the payload to be unloaded from different payloads and registering a total target quantity of the selected payload to be unloaded at the loading station as a target quantity unit, a current total quantity of the selected payload that has already been unloaded at the loading station as an actual quantity unit, a number of already performed unloading procedures corresponding to a quantity of the selected payload that has already been unloaded at the loading station, or a difference between the target quantity unit and the actual quantity unit.

Method for unloading a payload

A method for tipping out a cargo load from a reception unit includes providing the reception unit on a lifting device of a work machine, performing a tipping out process of a mass of cargo load from the reception unit, detecting a predetermined residual mass of the cargo load remaining in the reception unit, detecting a predetermined loading mass tipped out during the tipping step, and completing the tipping out process as a function of the predetermined residual mass or the predetermined loading mass.

Method for tipping out a cargo load

The present invention relates to a pharmaceutical composition comprising one or more pharmaceutically acceptable excipient(s) and a VEGF neutralizing prodrug, which comprises a VEGF neutralizing biologically active moiety, for use in a method for the treatment of one or more ocular conditions.

VEGF neutralizing prodrugs for the treatment of ocular conditions

The present invention relates to compounds comprising a protecting group moiety-tag moiety conjugate, a method of purification and monoconjugates obtained from such method of purification.

Protecting group comprising a purification tag

The present invention relates to a displacement sensor for contactlessly measuring a position of a magnet relative to a reference point. The displacement sensor comprises the magnet which can be displaced along a movement axis, a plurality of magnetic field sensors which are arranged in series and which are arranged parallel with the movement axis of the magnet and a calculation unit for forming a position signal which indicates the position of the magnet relative to the reference point. The plurality of magnetic field sensors which are arranged in series are arranged in such a manner that the displacement measurement ranges of adjacent magnetic field sensors overlap in an overlap range. The calculation unit is constructed in such a manner that, if the position of the magnet is contained in an overlap range, it forms the position signal on the basis of output signals which are output by the magnetic field sensors whose displacement measurement ranges overlap in the overlap range; and, if the position of the magnet is not contained in an overlap range, it forms the position signal on the basis of the output signal which is output by the magnetic field sensor, in the displacement measurement range of which the magnet is located. The overlap range between two displacement measurement ranges of adjacent magnetic field sensors is selected in such a manner that the total error of the position signal formed by the calculation unit in that overlap range is smaller than a maximum tolerable error.

Displacement sensor for contactlessly measuring a position by means of a plurality of magnetic field sensors arranged in series

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Heidelberg, Germany

Sebastian Stark