National University of Singapore

Singapore Health Services Pte Ltd

Boehringer Ingelheim International Gmbh

Sebastian Schaefer

Stuart Alexander Cook

Anissa Anindya Widjaja

Benjamin Wei Ming Ng

Brijesh Kumar Singh

Wei Wen Lim

An IL-11 binding receptor capable of binding to IL-11 and inhibiting IL-11 mediated signalling is disclosed. Also disclosed are compositions comprising the IL-11 binding receptor and methods using the IL-11 binding receptor.

Decoy cytokine receptor

Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Treatment of kidney injury

Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

Treatment of fibrosis

Methods of treating and preventing metabolic disease through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Treatment and prevention of metabolic diseases

Diagnosis, treatment and prophylaxis of diseases and conditions associated with smooth muscle cell (SMC) dysfunction are provided through the inhibition of IL-11-mediated signalling.

Treatment of SMC mediated disease

Methods of treating and preventing hepatotoxicity through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Treatment of hepatotoxicity with IL-11 antibody

Provided are antigen-binding molecules capable of binding to IL-11, and methods of medical treatment and prophylaxis using the same.

IL-11 antibodies

Provided are antigen-binding molecules capable of binding to IL-11R&#x3b1;, and methods of medical treatment and prophylaxis using the same.

IL-11R&#x3b1; antibodies

IL-11 antibodies are disclosed. Also disclosed are compositions comprising the IL-11 antibodies, and methods using the IL-11 antibodies.

IL-11R&#x3b1; antibodies are disclosed. Also disclosed are compositions comprising the IL-11R&#x3b1; antibodies, and methods using the IL-11R&#x3b1; antibodies.

Growing community of inventors

Singapore, Singapore

Sebastian Schaefer